Transient abnormal myelopoiesis in Down syndrome: Experience of long term follow up from a single tertiary center in Thailand

被引：1
作者：
Chotsampancharoen, Thirachit [1 ]
Chavananon, Shevachut [1 ]
Sripornsawan, Pornpun [1 ]
Songthawee, Natsaruth [1 ]
McNeil, Edward B. [2 ]
机构：
[1] Prince Songkla Univ, Fac Med, Dept Pediat, Hat Yai 90110, Thailand
[2] Prince Songkla Univ, Fac Med, Epidemiol Unit, Hat Yai, Thailand
来源：
PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2023年 / 40卷 / 02期
关键词：
Acute myeloid leukemia; Down syndrome; transient abnormal myelopoiesis; TUMOR LYSIS SYNDROME; MYELOPROLIFERATIVE DISORDER; NATURAL-HISTORY; LEUKEMIA; FIBROSIS; CHILDREN; INFANTS; RISK;
D O I：
10.1080/08880018.2022.2075501
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Transient abnormal myelopoiesis (TAM) is a unique disease occurring in Down syndrome (DS) infants from which most patients have spontaneous remission. This study aimed to evaluate the incidence and outcomes of TAM in a tertiary center in Thailand. We reviewed the records of 997 DS patients diagnosed between June 1993 and October 2019. From the 997 DS patients, 32 had been diagnosed with TAM. The incidence of TAM was 3.2% and an overall survival rate of 87.5%. A total of 2/28 who survived (7.1%) subsequently developed AML-DS at the ages of 2.1 and 4.5 years, respectively. The risk factors related with death included maternal multiparity, sepsis, skin bleeding, subcutaneous nodules, high WBC count, low hemoglobin, and elevated AST level. Abbreviations
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页码：108 / 116
页数：9
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