Multiple function of lncRNA MALAT1 in cancer occurrence and progression

被引：28

作者：

Malakoti, Faezeh ^{[1
,2
,3
]}

Targhazeh, Niloufar ^{[1
,2
]}

Karimzadeh, Haniye ^{[4
,5
]}

Mohammadi, Erfan ^{[6
,7
]}

Asadi, Milad ^{[7
]}

Asemi, Zatollah ^{[8
]}

Alemi, Forough ^{[1
,2
]}

机构：

[1] Tabriz Univ Med Sci, Fac Med, Dept Biochem, Tabriz, Iran

[2] Tabriz Univ Med Sci, Fac Med, Clin Labs, Tabriz, Iran

[3] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran

[4] Isfahan Univ Med Sci, Sch Pharm, Dept Clin Biochem, Esfahan, Iran

[5] Isfahan Univ Med Sci, Isfahan Pharmaceut Sci Res Ctr, Esfahan, Iran

[6] Univ Tabriz, Fac Nat Sci, Dept Biol, Tabriz, Iran

[7] Ege Univ, Hlth Inst, Dept Basic Oncol, Izmir, Turkey

[8] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2023年 / 101卷 / 05期

关键词：

BC; COC; HCC; Lung cancer; MALAT1; miRNAs; OC; OS; LONG NONCODING RNA; HUMAN HEPATOCELLULAR-CARCINOMA; EPITHELIAL OVARIAN-CANCER; BREAST-CANCER; CELL-PROLIFERATION; CISPLATIN-RESISTANCE; SIGNALING PATHWAY; DOWN-REGULATION; REGULATES PROLIFERATION; MESENCHYMAL TRANSITION;

D O I：

10.1111/cbdd.14006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long non-coding RNAs (lncRNAs) have received particular attention in the last decade due to its engaging in carcinogenesis and tumorigenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a lncRNA that plays physiological and pathological roles in many aspects of genome function as well as biological processes involved in cell development, differentiation, proliferation, invasion, and migration. In this article, we will review the effects of lncRNA MALAT1 on the progression of six prevalent human cancers by focusing on MALAT1 ability to regulate post-transcriptional modification and signaling pathways.

引用

页码：1113 / 1137

页数：25

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