The influence of GC-biased gene conversion on non-adaptive sequence evolution in short introns of Drosophila melanogaster

被引:0
作者
Yildirim, Burcin [1 ,2 ]
Vogl, Claus [1 ,2 ]
机构
[1] Vetmeduni, Dept Biomed Sci, Vet Pl 1, A-1210 Vienna, Austria
[2] Vienna Grad Sch Populat Genet, Vienna, Austria
基金
奥地利科学基金会;
关键词
neutral evolution; GC-biased gene conversion; recombination; linked selection; mutation rate; X-chromosome; Drosophila; CODON USAGE BIAS; EFFECTIVE POPULATION-SIZE; RECOMBINATION RATE; BASE COMPOSITION; DIRECTIONAL SELECTION; NONCODING SEQUENCES; MOLECULAR EVOLUTION; NATURAL-SELECTION; MORAN MODEL; PATTERNS;
D O I
10.1093/jeb/voae015
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
Population genetic inference of selection on the nucleotide sequence level often proceeds by comparison to a reference sequence evolving only under mutation and population demography. Among the few candidates for such a reference sequence is the 5' part of short introns (5SI) in Drosophila. In addition to mutation and population demography, however, there is evidence for a weak force favouring GC bases, likely due to GC-biased gene conversion (gBGC), and for the effect of linked selection. Here, we use polymorphism and divergence data of Drosophila melanogaster to detect and describe the forces affecting the evolution of the 5SI. We separately analyse mutation classes, compare them between chromosomes, and relate them to recombination rate frequencies. GC-conservative mutations seem to be mainly influenced by mutation and drift, with linked selection mostly causing differences between the central and the peripheral (i.e., telomeric and centromeric) regions of the chromosome arms. Comparing GC-conservative mutation patterns between autosomes and the X chromosome showed differences in mutation rates, rather than linked selection, in the central chromosomal regions after accounting for differences in effective population sizes. On the other hand, GC-changing mutations show asymmetric site frequency spectra, indicating the presence of gBGC, varying among mutation classes and in intensity along chromosomes, but approximately equal in strength in autosomes and the X chromosome. Graphical Abstract
引用
收藏
页码:383 / 400
页数:18
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