Alendronate-Grafted Nanoemulsions for Bone-Targeted Vincristine Delivery: Preliminary Studies on Cell and Animal Models

被引：2

作者：

Stoppa, Ian ^{[1
]}

Dianzani, Chiara ^{[2
]}

Clemente, Nausicaa ^{[1
]}

Bozza, Annalisa ^{[2
]}

Bordano, Valentina ^{[2
]}

Garelli, Sara ^{[2
]}

Cangemi, Luigi ^{[2
]}

Dianzani, Umberto ^{[1
]}

Battaglia, Luigi ^{[2
,3
]}

机构：

[1] Univ Eastern Piedmont UPO, Interdisciplinary Res Ctr Autoimmune Dis IRCAD, Dept Hlth Sci, Via Solaroli 17, I-28100 Novara, Italy

[2] Univ Turin, Dept Drug Sci & Technol, Via Pietro Giuria 9, I-10125 Turin, Italy

[3] Univ Turin, Nanostruct Interfaces & Surfaces NIS Interdept Ctr, I-10124 Turin, Italy

来源：

BIOMOLECULES | 2024年 / 14卷 / 02期

关键词：

nanoemulsion; alendronate; vincristine; GINGIVAL FIBROBLASTS; IN-VITRO; MIGRATION; PROLIFERATION; NANOPARTICLES; OSTEOBLASTS; INVASION;

D O I：

10.3390/biom14020238

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone is a site of distant metastases, which are a common cause of morbidity and mortality with a high socio-economic impact, for many malignant tumours. In order to engineer pharmacological therapies that are suitable for this debilitating disease, this experimental work presents injectable lipid nanoemulsions, which are endowed with a long history of safe clinical usage in parenteral nutrition, their loading with vincristine and their grafting with alendronate, with a dual purpose: merging the anticancer activity of bisphosphonates and vincristine, and enhancing bone-targeted delivery. In cell studies, alendronate synergised with the anti-migration activity of vincristine, which is important as migration plays a key role in the metastatisation process. In preliminary animal studies, carried out thanks to IVIS technology, alendronate conjugation enhanced the bone targeting of fluorescently labelled nanoemulsions. These encouraging results will drive further studies on suitable animal models of the disease.

引用

页数：18

共 40 条

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