CLPC1 protein inhibition, antimycobacterial, and anti-inflammatory properties of the metabolite from Streptomyces wuyuanensis collected in Nghe An province, Vietnam

被引：0

作者：

Ni, Huynh Thi Ngoc ^{[1
,2
]}

Ninh, Pham Thi ^{[3
]}

Dung, Nguyen Thi ^{[3
]}

Van Chien, Tran ^{[3
]}

Uyen, Nguyen Quynh ^{[4
]}

Anh, Ho Ngoc ^{[5
]}

Suh, Joo-Won ^{[6
]}

Cheng, Jinhua ^{[6
]}

Thao, Nguyen Kim Nu ^{[7
]}

Duc, Nguyen Minh ^{[8
,9
]}

Thao, Tran Thi Phuong ^{[1
,3
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Grad Univ Sci & Technol, Fac Chem, Hanoi, Vietnam

[2] Phu Yen Univ, Fac Nat Sci, Tuy Hoa City, Phu Yen, Vietnam

[3] Vietnam Acad Sci & Technol VAST, Inst Chem, 18 Hoang Quoc Viet, Hanoi 10000, Vietnam

[4] Vietnam Natl Univ, Inst Microbiol & Biotechnol, Lab Appl Mol Biol, Hanoi, Vietnam

[5] Vietnam Acad Sci & Technol VAST, Inst Biotechnol, Hanoi, Vietnam

[6] Myongji Univ, Myongji Bioefficacy Res Ctr, Yongin, Gyeonggi Do, South Korea

[7] Vietnam Natl Univ, Univ Nat Sci, Fac Biol, Hanoi, Vietnam

[8] Vietnam Acad Sci & Technol, Inst Genome Res, Hanoi, Vietnam

[9] Vietnam Acad Sci & Technol VAST, Inst Genome Res, 18 Hoang Quoc Viet, Hanoi 10000, Vietnam

来源：

VIETNAM JOURNAL OF CHEMISTRY | 2024年 / 62卷 / 01期

关键词：

antimycobacterial activity; ClpC1-protein; indole-3-carboxylic acid; Mycobacterium tuberculosis; Streptomyces wuyuanensis; PURIFICATION; EXPRESSION;

D O I：

10.1002/vjch.202300345

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Streptomyces wuyuanensis A79 was isolated from the soil samples collected in Quynh Luong mangrove forest, Quynh Luu district, Nghe An province, Vietnam. This strain demonstrated antimycobacterial activity against Mycobacterium smegmatis. Compound 1 (indole-3-carboxylic acid) was isolated from the culture extract of S. wuyuanensis (A79). This compound displayed the affection of ATPase activity of the recombinant ClpC1 protein, a regulatory protein of Mycobacterium tuberculosis. In addition, compound 1 exhibited anti-inflammatory activity through the inhibition of TNF-alpha on LPS-stimulated macrophage RAW264.7. This is the first time compound 1 (indole-3-carboxylic acid) has been isolated from S. wuyuanensis. Indole-3-carboxylic acid was also reported for the first time its inhibition of M. tuberculosis ClpC1 protein.

引用

页码：85 / 91

页数：7

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