Lower serum testosterone is associated with increased likelihood of arthritis

被引:7
作者
Cheng, Lulu [1 ,2 ]
Wang, Siyu [2 ]
机构
[1] Anhui Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Hefei 230012, Peoples R China
[2] Wuhan Sports Univ, Grad Sch, Wuhan 430079, Peoples R China
关键词
STEROID-HORMONES; SEX-HORMONES; GROWTH-PLATE; OSTEOARTHRITIS; KNEE; CHONDROCYTES; REPLACEMENT; SYMPTOMS; ESTROGEN; THERAPY;
D O I
10.1038/s41598-023-46424-1
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Studies have suggested that serum testosterone levels may be strongly correlated with the pathogenesis of arthritis. Therefore, the aim of this study was to assess the relationship between serum testosterone levels and arthritis in US adults using the National Health and Nutrition Examination Survey (NHANES). We used the database from NHANES, 2013-2016 to perform a cross-sectional study. This study investigated the relationship between serum testosterone and arthritis using multivariate logistic regression models and also used smoothed curve fitting and generalized additivity models. A total of 10,439 adults were included in this analysis. A significant negative association between serum testosterone and arthritis was found in a linear regression analysis. The study showed that the arthritis group had lower testosterone levels than the non-arthritis group. The univariate multivariate analyses of Q4, using Q1 as a reference, all showed a significantly lower risk of developing arthritis. In subgroup analyses, the negative correlation between serum testosterone levels and arthritis was more significant in women and those with a body mass index (BMI) >= 30 kg/m2. After controlling for various variables, we found a significant association between serum testosterone and arthritis in this analysis. Further study of the relationship between testosterone and arthritis is necessary to clarify the specific mechanism of serum testosterone action on arthritis.
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页数:9
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