Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose-induced oncogenic effect by downregulating the Warburg effect

被引：3

作者：

Yu, Chang ^{[1
]}

Min, Su ^{[1
]}

Lv, Feng ^{[1
]}

Ren, Li ^{[1
]}

Yang, You ^{[1
]}

Chen, Lihao ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, 1 Youyi Rd, Chongqing 400016, Peoples R China

来源：

MEDICAL ONCOLOGY | 2023年 / 40卷 / 10期

关键词：

Vitamin C; Cancer; Glucose; Warburg effect; Nutritional support; TUMOR-GROWTH; HYDROGEN-PEROXIDE; DIET;

D O I：

10.1007/s12032-023-02155-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malnutrition caused by insufficient nutritional supply may significantly hinder the quality of life among cancer patients. Sugar provides energy and nutritional support, but it also promotes cancer growth. Warburg effect is the reprogrammed glucose metabolic mode of cancer cells that meets the intensified ATP demand and biosynthesis. Vitamin C (VC) has anti-tumor effect. However, the relationship between cytotoxicity of VC on cancer cells and Warburg effect remains elusive, the effect of VC on glucose-induced oncogenic effect is also unclear. Based on colorectal cancer cell HCT116, our finding revealed that the discrepant oncogenic effect of different sugar is closely related to the intensification of Warburg effect, with glucose being the potent oncogenic component. Notably, as a potential Warburg effect inhibitor, VC suppressed cancer growth in a concentration-dependent manner and further reversed the glucose-induced oncogenic effect. Furthermore, VC protected tumor-bearing mice from insulin sensitivity impairment and inflammatory imbalance. These findings imply that VC might be a useful adjuvant treatment for cancer patients seeking to optimize nutritional support.

引用

页数：12

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