Apelin-13 as a Potential Biomarker in Critical Illness

被引:2
作者
Gergics, Marin [1 ,2 ]
Pham-Dobor, Greta [1 ,2 ]
Kurdi, Csilla [2 ,3 ]
Montsko, Gergely [2 ,3 ]
Mihalyi, Krisztina [4 ]
Banfai, Gabor [4 ]
Kanizsai, Peter [4 ]
Koszegi, Tamas [2 ,3 ]
Mezosi, Emese [1 ,2 ]
Bajnok, Laszlo [1 ,2 ]
机构
[1] Univ Pecs, Med Sch, Dept Internal Med 1, H-7624 Pecs, Hungary
[2] Univ Pecs, Jan Szentagotha Res Ctr, H-7624 Pecs, Hungary
[3] Univ Pecs, Med Sch, Dept Lab Med, H-7624 Pecs, Hungary
[4] Univ Pecs, Med Sch, Dept Emergency Med, H-7624 Pecs, Hungary
关键词
copeptin; apelin-13; free cortisol; CRH; critical illness; VASOPRESSIN PRECURSOR; STABLE PEPTIDE; COPEPTIN; MARKERS; AXIS; CORTISOL; SEPSIS; SERUM; APJ;
D O I
10.3390/jcm12144801
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The adrenocortical system and copeptin as prognostic markers were intensively investigated in critical illness. The potential predictive power of apelin-13 as a biomarker is largely unknown. We aimed to investigate the prognostic role of apelin-13 in relation to free cortisol, aldosterone, CRH, and copeptin in critically ill patients. Methods: In this prospective observational study, 124 critically ill patients (64 men, 60 women, median age: 70 (59-78) years) were consecutively enrolled at the time of admission. All routinely available clinical and laboratory parameters were evaluated and correlated to hormonal changes. Results: Serum apelin-13 was 1161 (617-2967) pg/mL in non-survivors vs. 2477 (800-3531) pg/mL in survivors (p = 0.054). The concentrations of apelin-13 and CRH had strong positive correlations (r = 0.685, p < 0.001) and were significantly higher in surviving non-septic patients (Apelin-13 (pg/mL): 2286 (790-3330) vs. 818 (574-2732) p < 0.05; CRH (pg/mL) 201 (84-317) vs. 89 (74-233) p < 0.05). Apelin-13 and free cortisol were independent determinants of survival in the multivariate Cox regression analysis, while copeptin, CRH, or aldosterone were not. Conclusions: Beyond free cortisol, serum apelin-13 may also help refine prognostic predictions in the early phase of critical illness, especially in non-septic patients.
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页数:11
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