Myocardial Injury and Prognosis in Hospitalized COVID-19 Patients in Brazil: Results From The Brazilian COVID-19 Registry

被引：1

作者：

Barbosa, Hannah Cardoso ^{[1
]}

Martins, Maria Auxiliadora Parreiras ^{[1
]}

de Jesus, Jordana Cristina ^{[2
]}

Meira, Karina Cardoso ^{[2
]}

Passaglia, Luiz Guilherme ^{[1
]}

Sacioto, Manuela Furtado ^{[3
]}

Bezerra, Adriana Falangola Benjamin ^{[4
]}

Schwarzbold, Alexandre Vargas ^{[5
,17
]}

Maurilio, Amanda de Oliveira ^{[6
]}

Farace, Barbara Lopes ^{[7
]}

da Silva, Carla Thais Candida Alves ^{[8
]}

Cimini, Christiane Correa Rodrigues ^{[9
,10
]}

Silveira, Daniel Vitorio ^{[11
]}

Carazai, Daniela do Reis ^{[12
]}

Ponce, Daniela ^{[13
]}

Costa, Emanuel Victor Alves ^{[14
]}

Manenti, Euler Roberto Fernandes ^{[15
]}

Cenci, Evelin Paola de Almeida ^{[16
]}

Bartolazzi, Frederico ^{[8
]}

Madeira, Glicia Cristina de Castro ^{[3
]}

Nascimento, Guilherme Fagundes ^{[11
]}

Velloso, Isabela Vasconcellos Pires ^{[17
]}

Batista, Joanna d'Arc Lyra ^{[18
,19
]}

de Morais, Julia Drumond Parreiras ^{[20
]}

Carvalho, Juliana da Silva Nogueira ^{[4
]}

Ruschel, Karen Brasil ^{[15
,21
]}

Martins, Karina Paula Medeiros Prado ^{[1
,21
]}

Zandona, Liege Barella ^{[22
]}

Menezes, Luanna Silva Monteiro ^{[23
,24
]}

Kopittke, Luciane ^{[12
]}

de Castro, Luis Cesar ^{[22
]}

Nasi, Luiz Antonio ^{[25
]}

Floriani, Maiara Anschau ^{[24
,25
]}

Souza, Maira Dias

Carneiro, Marcelo ^{[26
]}

Bicalho, Maria Aparecida Camargos ^{[27
]}

Lima, Maria Clara Pontello Barbosa ^{[28
]}

de Godoy, Mariana Frizzo ^{[29
]}

Guimaraes-Junior, Milton Henriques ^{[30
]}

Mendes, Paulo Mascarenhas ^{[17
]}

Delfino-Pereira, Polianna ^{[21
]}

Ribeiro, Raquel Jaqueline Eder ^{[29
]}

Finger, Renan Goulart ^{[19
]}

Menezes, Rochele Mosmann ^{[26
]}

Francisco, Saionara Cristina ^{[31
]}

Araujo, Silvia Ferreira ^{[32
]}

Oliveira, Talita Fischer ^{[24
]}

de Oliveira, Thainara Conceicao ^{[16
]}

Polanczyk, Carisi Anne ^{[21
]}

Marcolino, Milena Soriano ^{[21
]}

机构：

[1] Univ Fed Minas Gerais, Hosp Clin, Ave Prof Alfredo Balena 110, BR-30130100 Belo Horizonte, MG, Brazil

[2] Univ Fed Rio Grande do Norte, Natal, RN, Brazil

[3] Fac Ciencias Med Minas Gerais, Belo Horizonte, MG, Brazil

[4] Univ Fed Pernambuco, Hosp Clin, Recife, PE, Brazil

[5] Hosp Univ Santa Maria, Santa Maria, RS, Brazil

[6] Hosp Sao Joao Deus, Divinopolis, MG, Brazil

[7] Hosp Risoleta Tolentino Neves, Belo Horizonte, MG, Brazil

[8] Hosp Santo Antonio, Curvelo, MG, Brazil

[9] Hosp Santa Rosalia, Teofilo Otoni, MG, Brazil

[10] Univ Fed Vales Jequitinhonha & Mucuri, Teofilo Otoni, MG, Brazil

[11] Hosp UNIMED BH, Belo Horizonte, MG, Brazil

[12] Hosp Nossa Senhora Conceicao, Porto Alegre, RS, Brazil

[13] Univ Estadual Paulista, Botucatu, SP, Brazil

[14] Ctr Univ Belo Horizonte UniBH, Belo Horizonte, MG, Brazil

[15] Hosp Mae Deus, Porto Alegre, RS, Brazil

[16] Hosp Univ Canoas, Canoas, RS, Brazil

[17] Hosp Rede Mater Dei, Belo Horizonte, MG, Brazil

[18] Univ Fed Fronteira Sul, Chapeco, SC, Brazil

[19] Hosp Reg Oeste, Chapeco, SC, Brazil

[20] Hosp Univ Ciencias Med, Belo Horizonte, MG, Brazil

[21] Inst Avaliacao Tecnol Saude IATS CNPq, Porto Alegre, RS, Brazil

[22] Hosp Bruno Born, Lajeado, RS, Brazil

[23] Hosp Luxemburgo, Belo Horizonte, MG, Brazil

[24] Hosp Municipal Odilon Behrens, Belo Horizonte, MG, Brazil

[25] Hosp Moinhos Vento, Porto Alegre, RS, Brazil

[26] Hosp Santa Cruz, Santa Cruz Do Sul, RS, Brazil

[27] Hosp Reg Antonio Dias, Patos De Minas, MG, Brazil

[28] Univ Fed Ouro Preto, Ouro Preto, MG, Brazil

[29] Hosp Sao Lucas PUCRS, Porto Alegre, RS, Brazil

[30] Hosp Marcio Cunha, Ipatinga, MG, Brazil

[31] Hosp Metropolitano Doutor Celio de Castro, Belo Horizonte, MG, Brazil

[32] Hosp Semper, Belo Horizonte, MG, Brazil

来源：

ARQUIVOS BRASILEIROS DE CARDIOLOGIA | 2023年 / 120卷 / 02期

关键词：

COVID-19; Coronavirus Infections; Troponin; Artificial Respiration; Mortality;

D O I：

10.36660/abc.20220151

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Cardiovascular complications of COVID-19 are important aspects of the disease's pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives: To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods: This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05.Results: Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels.Conclusion: Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.

引用

页数：12

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