Synthesis and Structure-Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives

被引：2
作者：
Yang, Yazhou [1 ]
Zhou, Yujie [1 ]
Jiang, Qiaoju [1 ]
Tan, Yi [1 ]
Wu, Wenbin [1 ]
Han, Ke [1 ]
Zhu, Rui [1 ]
Zheng, Shaojun [1 ]
机构：
[1] Jiangsu Univ Sci & Technol, Sch Environm & Chem Engn, Zhenjiang 212003, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 06期
基金：
中国国家自然科学基金;
关键词：
cyclotryptamine alkaloids; synthesis; biological activity; agrochemicals; SAR; CONCISE TOTAL-SYNTHESIS; ANTIBACTERIAL ACTIVITY;
D O I：
10.3390/molecules28062617
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A total of 39 novel cyclotryptamine alkaloid derivatives were prepared from 2-(1H-indol-3-yl) acetonitrile. The prepared compounds were evaluated against six plant pathogen fungi. Bioassay results revealed that most of the compounds displayed higher in vitro antifungal activities than the positive control. Notably, compound b2 displayed the broadest and most effective activity among the tested cyclotryptamine alkaloid derivatives and might be a novel potential leading compound for further development as an antifungal agent.
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页数：14
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