Is incident cancer in later life associated with lower incidence of dementia?

被引：1

作者：

Almeida, Osvaldo P. ^{[1
,2
,8
]}

Hankey, Graeme J. ^{[1
,3
]}

Yeap, Bu B. ^{[1
,4
]}

Golledge, Jonathan ^{[5
,6
]}

Etherton-Beer, Christopher ^{[1
,2
]}

Robinson, Suzanne ^{[7
]}

Flicker, Leon ^{[1
,2
]}

机构：

[1] Univ Western Australia, Med Sch, Perth, Australia

[2] Univ Western Australia, WA Ctr Hlth & Ageing, Perth, Australia

[3] Sir Charles Gairdner Hosp, Dept Neurol, Perth, Australia

[4] Fiona Stanley Hosp, Dept Endocrinol & Diabet, Perth, Australia

[5] James Cook Univ, Coll Med & Dent, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Australia

[6] Townsville Hosp, Dept Vasc & Endovascular Surg, Townsville, Australia

[7] Deakin Univ, Deakin Hlth Econ, Geelong, Vic, Australia

[8] Univ Western Australia, WA Ctr Health& Ageing M577, 35 Stirling Highway, Perth, WA 6009, Australia

来源：

INTERNATIONAL PSYCHOGERIATRICS | 2024年 / 36卷 / 12期

基金：

英国医学研究理事会;

关键词：

cancer; dementia; Alzheimer's disease (AD); epidemiology; LENGTH;

D O I：

10.1017/S1041610222001119

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Cancer has been associated with lower risk of dementia, although methodological issues raise concerns about the validity of this association. We recruited 31,080 men aged 65-85 years who were free of cancer and dementia, and followed them for up to 22 years. We used health record linkage to identify incident cases of cancer and dementia, and split time span to investigate this association. 18,693 (60.1%) and 6897 (22.2%) participants developed cancer and dementia during follow-up. The hazard ratio (HR) of dementia associated with cancer was 1.13 (95% CI = 1.07, 1.20) and dropped to 0.85 (95% CI = 0.80, 0.91) when 449 participants who developed dementia within 2 years were excluded. The diagnosis of cancer seems to facilitate the early detection of dementia cases. Older participants who survive cancer for 2 or more years have lower risk of receiving the diagnosis of dementia over time. The factors that mediate this association remain unclear.

引用

页码：1251 / 1255

页数：5

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