Sex differences in the age-related decrease of spontaneous baroreflex function in healthy individuals

被引:1
|
作者
Schumann, Andy [1 ]
Gupta, Yubraj [1 ]
Gerstorf, Denis [2 ]
Demuth, Ilja [3 ]
Bar, Karl-Jurgen [1 ]
机构
[1] Jena Univ Hosp, Dept Psychosomat Med & Psychotherapy, Lab Auton Neurosci Imaging & Cognit, Jena, Germany
[2] Humboldt Univ, Dept Psychol, Berlin, Germany
[3] Charite Univ Med Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2024年 / 326卷 / 01期
关键词
autonomic nervous system; blood pressure; cardiovagal function; heart rate variability; HEART-RATE-VARIABILITY; BLOOD-PRESSURE; NEURAL-CONTROL; SENSITIVITY; RISK; MEN; HYPERTENSION; TACHYCARDIA; BIOFEEDBACK; DEPENDENCY;
D O I
10.1152/ajpheart.00648.2023
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The baroreflex is a powerful physiological mechanism for rapidly adjusting heart rate in response to changes in blood pressure. Spontaneous baroreflex sensitivity (BRS) has been shown to decrease with age. However, studies of sex differences in these age-related changes are rare. Here we investigated several markers of spontaneous baroreflex function in a large sample of healthy individuals. Cardiovascular signals were recorded in the supine position under carefully controlled resting conditions. After quality control, n = 980 subjects were divided into five age groups [age < 30 yr (n = 612), 30-39 yr (n = 140), 40-49 yr (n = 95), 50-59 yr (n = 61), and >60 yr (n = 72)]. Spontaneous baroreflex function was assessed in the time domain (bradycardic and tachycardic slope) and in the frequency domain in the low- and high-frequency band (LF-alpha, HF-alpha) applying the transfer function. General linear models showed a significant effect of factor age (P < 0.001) and an age x sex interaction effect (P < 0.05) on each indicator of the baroreflex function. Simple main effects showed a significantly higher BRS as indicated by tachycardic slope, LF-alpha and HF-alpha in middle-aged women compared with men (30-39 yr) and higher LF-alpha, bradycardic and tachycardic slope in men compared with women of the oldest age group (>60 yr). Changes in BRS over the lifespan suggest that baroreflex function declines more slowly but earlier in life in men than in women. Our findings could be linked to age-related changes in major sex hormone levels, suggesting significant implications for diverse cardiovascular outcomes and the implementation of targeted preventive strategies.
引用
收藏
页码:H158 / H165
页数:8
相关论文
共 50 条
  • [31] AGE-RELATED AND SEX-RELATED DIFFERENCES IN URINARY CORTISOL LEVEL
    NAKAMURA, J
    YAKATA, M
    CLINICA CHIMICA ACTA, 1984, 137 (01) : 77 - 80
  • [32] Age-related differences in foot mobility in individuals with patellofemoral pain
    Tan, Jade M.
    Crossley, Kay M.
    Vicenzino, Bill
    Menz, Hylton B.
    Munteanu, Shannon E.
    Collins, Natalie J.
    JOURNAL OF FOOT AND ANKLE RESEARCH, 2018, 11
  • [33] Age-related differences in foot mobility in individuals with patellofemoral pain
    Jade M. Tan
    Kay M. Crossley
    Bill Vicenzino
    Hylton B. Menz
    Shannon E. Munteanu
    Natalie J. Collins
    Journal of Foot and Ankle Research, 11
  • [34] The associations among glycemic control, heart variability, and autonomic brain function in healthy individuals: Age- and sex-related differences
    Yu, Jeffrey X.
    Hussein, Ahmad
    Mah, Linda
    Chen, J. Jean
    NEUROBIOLOGY OF AGING, 2024, 142 : 41 - 51
  • [35] Sex and Age-Related Differences in Complement Factors Among Patients With Intermediate Age-Related Macular Degeneration
    Marin, A. Itzam
    Poppelaars, Felix
    Wagner, Brandie D.
    Palestine, Alan G.
    Patnaik, Jennifer L.
    Holers, V. Michael
    Frazer-Abel, Ashley A.
    Mathias, Marc T.
    Manoharan, Niranjan
    Fonteh, Cheryl N.
    Mandava, Naresh
    Lynch, Anne M.
    TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2022, 11 (05):
  • [36] Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children
    Katherine R. Dobbs
    Paula Embury
    Emmily Koech
    Sidney Ogolla
    Stephen Munga
    James W. Kazura
    Arlene E. Dent
    Immunity & Ageing, 18
  • [37] Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children
    Dobbs, Katherine R.
    Embury, Paula
    Koech, Emmily
    Ogolla, Sidney
    Munga, Stephen
    Kazura, James W.
    Dent, Arlene E.
    IMMUNITY & AGEING, 2021, 18 (01)
  • [38] Sex differences in baroreflex function in health and disease
    Qi Fu
    Shigehiko Ogoh
    The Journal of Physiological Sciences, 2019, 69 : 851 - 859
  • [39] Sex differences in baroreflex function in health and disease
    Fu, Qi
    Ogoh, Shigehiko
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2019, 69 (06): : 851 - 859
  • [40] Sex Differences in Age-Related Loss of Kidney Function (vol 33, pg 1891, 2022)
    Melsom, Toralf
    Norvik, Jon Viljar
    Enoksen, Inger Therese
    Stefansson, Vidar
    Mathisen, Ulla Dorte
    Fuskevag, Ole Martin
    Jenssen, Trond G.
    Solbu, Marit D.
    Eriksen, Bjorn O.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2024, 35 (08): : 1137 - 1137