Association of Dental Diseases and Oral Hygiene Care With the Risk of Heart Failure in Patients With Type 2 Diabetes: A Nationwide Cohort Study

被引：10

作者：

Huh, Youn ^{[1
]}

Yoo, Jung Eun ^{[2
]}

Park, Sang-Hyun ^{[3
]}

Han, Kyungdo ^{[4
]}

Kim, Seon Mee ^{[5
]}

Park, Hye Soon ^{[6
]}

Cho, Kyung Hwan ^{[7
]}

Ahn, Jin-Soo ^{[8
,9
]}

Jun, Sang Ho ^{[10
,12
]}

Nam, Ga Eun ^{[5
,11
]}

机构：

[1] Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Family Med, Uijongbu, Gyeonggi Do, South Korea

[2] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Family Med, Seoul, South Korea

[3] Catholic Univ Korea, Coll Med, Dept Med Stat, Seoul, South Korea

[4] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea

[5] Korea Univ, Guro Hosp, Dept Family Med, Coll Med, Seoul, South Korea

[6] Univ Ulsan, Asan Med Ctr, Dept Family Med, Coll Med, Seoul, South Korea

[7] Korea Univ, Coll Med, Dept Family Med, Anam Hosp, Seoul, South Korea

[8] Seoul Natl Univ, Sch Dent, Dept Dent Biomat Sci, Seoul, South Korea

[9] Seoul Natl Univ, Dent Res Inst, Sch Dent, Seoul, South Korea

[10] Korea Univ Anam Hosp, Dept Oral & Maxillofacial Surg, Seoul, South Korea

[11] Korea Univ, Coll Med, Dept Family Med, Guro Hosp, 148 Gurodong Ro, Seoul 08308, South Korea

[12] Korea Univ, Dept Oral & Maxillofacial Surg, Anam Hosp, 73 Goryeodae Ro, Seoul 02841, South Korea

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2023年 / 12卷 / 16期

基金：

新加坡国家研究基金会;

关键词：

dental caries; heart failure; missing teeth; oral hygiene care; periodontal disease; type; 2; diabetes; PERIODONTAL-DISEASE; MICROBIOTA; HEALTH;

D O I：

10.1161/JAHA.122.029207

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundTo evaluate the association of dental diseases and oral hygiene care with incidence of heart failure (HF) among patients with type 2 diabetes. Methods and ResultsThis study included 173 927 patients with type 2 diabetes aged & GE;40 years, who underwent Korean National Health Insurance Service health examinations in 2008 and were followed up until the end of 2017. Hazard ratios (HRs) and 95% CIs for HF were estimated using multivariable Cox proportional hazards regression analysis. During a median follow-up of 9.3 years, 1.94% of participants developed HF. An increased number of missing teeth was associated with a higher risk of HF (P<0.001). HRs of HF increased among individuals with & GE;15 missing teeth (HR, 1.37 [95% CI, 1.14-1.64]) compared with those without missing teeth. Decreased risk of HF was observed in individuals with & GE;1 time/year of professional dental cleaning (HR, 0.93 [95% CI, 0.87-0.99]) and in those with & GE;2 times/d of toothbrushing (HR, 0.90 [95% CI, 0.82-0.98]) compared with those without these practices. While combined presence of missing teeth and periodontal disease (P=0.004) or dental caries (P=0.007) increased HF risk, combined oral hygiene care was associated with further HF risk reduction (P=0.024). Better oral hygiene care was associated with decreased HF risk, even as the number of missing teeth increased (P<0.001). ConclusionsAmong patients with type 2 diabetes, dental diseases and oral hygiene care are important determinants of HF development. Dental disease management and good oral care may prevent HF in patients with type 2 diabetes.

引用

页数：10

共 31 条

[1] The Global Health and Economic Burden of Hospitalizations for Heart Failure Lessons Learned From Hospitalized Heart Failure Registries [J].