Cell phenotypes as activity biomarkers in patients with Systemic Lupus Erythematosus

被引：0

作者：

Loures, Cristina de Mello Gomide ^{[1
]}

Guimaraes, Tania Mara Pinto Dabes ^{[1
]}

Ferreira, Karine Silveste ^{[1
]}

Silva, Marcos Vinicius Ferreira ^{[1
]}

Alves, Luan Carlos Vieira ^{[1
]}

Cicarini, Walter Batista ^{[1
]}

Nunes, Fernanda Freire Campos ^{[1
]}

Consoli, Renato Vargas ^{[2
]}

Neiva, Claudia Lopes Santoro ^{[2
]}

de Padua, Paulo Madureira ^{[2
]}

dos Santos, Luara Isabela ^{[3
]}

Moreira, Josimar Dornelas ^{[1
]}

de Toledo, Vicente de Paulo Coelho Peixoto ^{[1
]}

Carvalho, Maria das Gracas ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Pharm, Dept Clin & Toxicol Anal, R Prof Moacir Gomes de Freitas, BR-31270901 Belo Horizonte, MG, Brazil

[2] Santa Casa, Dept Rheumatol, Belo Horizonte, MG, Brazil

[3] Fundacao Oswaldo Cruz, Belo Horizonte, MG, Brazil

来源：

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2023年 / 59卷

关键词：

Systemic Lupus Erythematosus; Lupus nephritis; T cells; B cells; NK cells; REGULATORY T-CELLS; DISEASE-ACTIVITY INDEX; NATURAL-KILLER-CELLS; NEW-ONSET; NEPHRITIS; TH17; SLE; LYMPHOCYTES; ACTIVATION; EXPRESSION;

D O I：

10.1590/s2175-97902023e20052

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pathogenesis of systemic lupus erythematosus (SLE) is complex. Few studies in Brazilian population have addressed cell phenotypes associated with immunological responses and their associations with SLE activity. The aim of this study is to investigate cell phenotypes associated to SLE diagnosis, treatment and activity. Twenty-eight SLE female patients (17 inactive, 11 active) and 10 healthy women were included in this study. Markers of natural killer (Nk), T and B cells in peripheral blood were evaluated by flow cytometry. Nkt cells were decreased only in SLE active patients. Activated CD4+, regulatory T FoxP3+ and B cells were decreased in both active and inactive SLE patients, compared to control group. The data corroborate the disruption of immune regulatory response in SLE patients and suggest phenotipic changes as possible biomarkers of SLE activity.

引用

页数：11

共 41 条

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