Recent advances in drug delivery systems based on natural and synthetic polymes for treating obesity

被引:8
作者
Xiao, Miaomiao [1 ,2 ]
Wang, Zongheng [3 ]
Li, Chang [4 ]
Zhang, Kai [5 ]
Hou, Zhipeng [1 ]
Sun, Siyu [5 ]
Yang, Liqun [1 ,6 ]
机构
[1] China Med Univ, Shengjing Hosp, Res Ctr Biomed Mat, Engn Res Ctr,Minist Educ Minimally Invas Gastroint, Shenyang 110004, Peoples R China
[2] Shenyang Sport Univ, Coll Exercise & Hlth, Shenyang 110102, Peoples R China
[3] Dalian Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, Dalian 116023, Peoples R China
[4] Wuhan Sports Univ, Coll Sports Med, Wuhan 430079, Peoples R China
[5] China Med Univ, Shengjing Hosp, Minist Educ Minimally Invas Gastrointestinal Endos, Endoscop Ctr,Engn Res Ctr,Dept Gastroenterol, Shenyang 110004, Peoples R China
[6] China Med Univ, Liaoning Res Inst Eugen Birth & Fertil, Shenyang 110031, Peoples R China
基金
中国国家自然科学基金;
关键词
Natural polymers; Drug delivery system; Obesity; DIET-INDUCED OBESITY; BODY-MASS INDEX; ADIPOSE-TISSUE; HYDROGELS; PEG; BIODEGRADATION; MICROPARTICLES; NANOPARTICLES; INFLAMMATION; COUNTRIES;
D O I
10.1016/j.ijbiomac.2024.129311
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Obesity stands as a pervasive global public health issue, posing a formidable threat to human well-being as its prevalence continues to surge year by year. Presently, pharmacological treatment remains the favored adjunct strategy for addressing obesity. However, conventional delivery methods suffer from low bioavailability and the potential for side effects, underscoring the pressing need for more efficient and targeted delivery approaches. Recent research has delved extensively into emerging drug delivery systems employing polymers as carriers, with numerous preclinical studies contributing to the growing body of knowledge. This review concentrates on the utilization of natural polymers as drug delivery systems for the treatment of obesity, encompassing recent advancements in both natural and synthetic polymers. The comprehensive exploration includes an analysis of the advantages and disadvantages associated with these polymer carriers. The examination of these characteristics provides valuable insights into potential future developments in the field of drug delivery for obesity treatment.
引用
收藏
页数:14
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