Uveitis Associated with Monogenic Autoinflammatory Syndromes in Children

被引：4
作者：
Maghsoudlou, P. [1 ]
Abraham, A. R. [1 ]
El-Ashry, M. [2 ]
Chew, C. [3 ,4 ]
Mohd, N. [2 ]
Ramanan, A. V. [3 ]
Dick, A. D. [1 ,4 ,5 ,6 ,7 ]
机构：
[1] Univ Bristol, Bristol Med Sch, Translat Hlth Sci, Acad Unit Ophthalmol, Bristol, England
[2] Bristol Eye Hosp, Dept Paediat Ophthalmol, Bristol, England
[3] Univ Bristol, Dept Paediat Rheumatol, Bristol, England
[4] Univ Bristol, Sch Cellular & Mol Med, Bristol, England
[5] UCL Inst Ophthalmol, London, England
[6] NIHR Biomed Res Ctr Moorfields, London, England
[7] UCL Inst Ophthalmol, Inst Ophthalmol, 11-43 Bath St, London EC1V 9EL, England
来源：
OCULAR IMMUNOLOGY AND INFLAMMATION | 2023年 / 31卷 / 10期
基金：
英国医学研究理事会;
关键词：
Autoinflammation; cytokine; inflammasome; inflammation; uveitis; FAMILIAL MEDITERRANEAN FEVER; BLAU SYNDROME; PERIODIC SYNDROME; CANAKINUMAB TREATMENT; SAFETY PROFILE; TNF RECEPTOR; HYPER-IGD; DISEASES; TOCILIZUMAB; THALIDOMIDE;
D O I：
10.1080/09273948.2023.2282610
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Monogenic autoinflammatory syndromes (MAISs), are caused by pathogenic genetic variants in the innate immune system, leading to dysregulation and aberrant inflammasome activation spontaneously or with minimal triggering. The diagnosis and treatment of MAISs can be intricate, relying on an increased recognition of potential differential diagnoses. This review examines the clinical features of MAIS, with a special focus on uveitis. It also evaluates treatment options and assesses the effects of activating molecular and cytokine pathways.
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收藏
页码：1930 / 1943
页数：14
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