Copper and Zinc Metal-Organic Frameworks with Bipyrazole Linkers Display Strong Antibacterial Activity against Both Gram plus and Gram- Bacterial Strains

被引：9

作者：

Xhafa, Sonila ^{[1
]}

Olivieri, Laura ^{[1
]}

Di Nicola, Corrado ^{[1
]}

Pettinari, Riccardo ^{[2
]}

Pettinari, Claudio ^{[2
]}

Tombesi, Alessia ^{[2
]}

Marchetti, Fabio ^{[1
]}

机构：

[1] Univ Camerino, ChIP Res Ctr, Sch Sci & Technol, Via Madonna Carceri, I-62032 Camerino, MC, Italy

[2] Univ Camerino, ChIP Res Ctr, Sch Pharm, Via Madonna Carceri, I-62032 Camerino, MC, Italy

来源：

MOLECULES | 2023年 / 28卷 / 16期

关键词：

Cu(II) and Zn(II) MOFs; bis(pyrazolate) ligands; antibacterial activity; chelation theory; ROS generation;

D O I：

10.3390/molecules28166160

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here, we report a new synthetic protocol based on microwave-assisted synthesis (MAS) for the preparation of higher yields of zinc and copper in MOFs based on different bis(pyrazolyl)-tagged ligands ([M(BPZ)]n where M = Zn(II), Cu(II), H2BPZ = 4,4 '-bipyrazole, [M(BPZ-NH2)]n where M = Zn(II), Cu(II); H2BPZ-NH2 = 3-amino-4,4 '-bipyrazole, and [Mx(Me4BPZPh)] where M = Zn(II), x = 1; Cu(II), x = 2; H2Me4BPZPh = bis-4 '-(3 ',5 '-dimethyl)-pyrazolylbenzene) and, for the first time, a detailed study of their antibacterial activity, tested against Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria, as representative agents of infections. The results show that all MOFs exert a broad-spectrum activity and strong efficiency in bacterial growth inhibition, with a mechanism of action based on the surface contact of MOF particles with bacterial cells through the so-called "chelation effect" and reactive oxygen species (ROS) generation, without a significant release of Zn(II) and Cu(II) ions. In addition, morphological changes were elucidated by using a scanning electron microscope (SEM) and bacterial cell damage was further confirmed by a confocal laser scanning microscopy (CLSM) test.

引用

页数：12