Primary cutaneous T-cell lymphoma: a review of the most common entities with focus on recent updates*

被引:2
作者
Saleh, Jasmine S. [1 ,2 ]
Subtil, Antonio [3 ]
Hristov, Alexandra C. [1 ,2 ,4 ]
机构
[1] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
[3] Univ British Columbia, Royal Jubilee Hosp, Dept Pathol, Victoria, BC V8R1J8, Canada
[4] Pathol & Dermatol, 2800 Plymouth Rd,Bldg 35, Ann Arbor, MI 48109 USA
关键词
primary cutaneous T -cell; Histopathology; Immunohistochemistry; Review with updates; lymphoma; and treatment; CD30-POSITIVE LYMPHOPROLIFERATIVE DISORDERS; FOLLICULOTROPIC MYCOSIS-FUNGOIDES; GRANULOMATOUS SLACK SKIN; TNM CLASSIFICATION-SYSTEM; SEZARY-SYNDROME; INTERNATIONAL-SOCIETY; PROGNOSTIC-FACTORS; CLINICOPATHOLOGICAL FEATURES; EUROPEAN-ORGANIZATION; TASK-FORCE;
D O I
10.1016/j.humpath.2023.09.009
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Cutaneous T-cell lymphomas are an heterogeneous group of uncommon lymphoid neoplasms that are challenging to diagnose and require close collaboration between dermatologists, pathologists and hematologists/oncologists. This article reviews the most common cutaneous T-cell lymphomas: mycosis fungoides (both classic and variant forms) as well as its leukemic counterpart Se ' zary syndrome, CD30+ T-cell lymphoproliferative disorders including the ever-expanding group of lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma, and primary cutaneous CD4+ small/medium lymphoproliferative disorder. We discuss the classic clinical and histopathologic features of these lymphomas and review how they can be distinguished from reactive entities. In particularly, updates to these diagnostic categories and current controversies in classification are highlighted. Moreover, we review the prognosis and treatment for each entity. These lymphomas exhibit variable prognosis, and therefore it is important to correctly classify atypical cutaneous T-cell infiltrates for appropriate patient treatment and prognosis. Cutaneous T-cell lymphomas are at the interface of several medical specialties; this review seeks to summarize key features of these lymphomas and highlight new and emerging insights into these lymphomas. (c) 2023 Elsevier Inc. All rights reserved.
引用
收藏
页码:75 / 100
页数:26
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