Risk factors for post-acute sequelae of COVID-19 in hospitalized patients: An observational study based on a survey in a tertiary care center in Türkiye

被引:1
作者
Yildiz, Yesim [1 ]
Ozturk Sahin, Burcu [2 ]
Tasdemir, Mert Can [3 ]
Demir, Serife [3 ]
Cifci, Beyza [1 ]
Kokturk, Nurdan [3 ]
Ulukavak Ciftci, Tansu [3 ]
Yurdakul, Ahmet Selim [3 ]
Yilmaz Demirci, Nilguen [3 ]
Aydogdu, Muege [3 ]
Dizbay, Murat [1 ]
Oguzulgen, Ipek Kivilcim [3 ]
机构
[1] Gazi Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkiye
[2] Sehitkamil State Hosp, Clin Pulm, Gaziantep, Turkiye
[3] Gazi Univ, Fac Med, Dept Pulm, Ankara, Turkiye
来源
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX | 2023年 / 71卷 / 03期
关键词
COVID-19; post-acute COVID-19 syndrome; risk factor; SARS-CoV-2; infection; long COVID;
D O I
10.5578/tt.20239707
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Introduction: Long COVID is a multisystem disease with various symptoms and risk factors. We aim to investigate the post-acute sequelae of COVID-19 and related risk factors in a tertiary care center.Materials and Methods: In this observational study, based on a survey of 1.977 COVID-19 patients hospitalized from April 2020 to January 2021, a retrospective assessment was carried out on 1.050 individuals who were reachable via telephone to determine their eligibility for meeting the inclusion criteria.Results: The data of 256 patients who reported at least one persistent symptom were analyzed. Long COVID prevalence was 24.3%. Among 256 patients (median age 52.8; 52.7% female; 56.63% had at least one comorbidity), dyspnea, fatigue, arthralgia-myalgia, cough, and back pain were the most common post-acute sequelae of COVID-19 (42.4%; 28.29%; 16.33%; 13.15% and 7.17%, respectively). The risk factors for the persistence of dyspnea included having lung diseases such as chronic obstructive pulmonary disease, a history of intensive care support, the requirement for long-term oxygen therapy, and a history of cytokine storm (p= 0.024, p= 0.026, p< 0.001, p= 0.036, p= 0.005, respectively). The correlation between lung involvement with post-discharge cough (p= 0.041) and dizziness (p= 0.038) was significant. No correlation between the symptoms with the severity of acute infection, age, and gender was found. When a multivariate regression analysis was conducted on the most common long COVID-related symptoms, several independent risk factors were identified. These included having lung disease for dyspnea (OR 5.81, 95% CI 1.08-31.07, p= 0.04); length of hospital stay for myalgia (OR 1.034, 95% CI 1.004-1.065, p= 0.024); and pulmonary involvement of over 50% during COVID-19 infection for cough (OR 3.793, 95% CI 1.184-12.147, p= 0.025).Conclusion: COVID-19 survivors will require significant healthcare services due to their prolonged symptoms. We hope that our findings will guide the management of these patients in clinical settings towards best practices.
引用
收藏
页码:261 / 272
页数:12
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