Does prenatal exposure to multiple airborne and tap-water pollutants increase neonatal thyroid-stimulating hormone concentrations? Data from the Picardy region, France

被引:10
作者
Chamot, Sylvain [1 ,2 ,12 ]
Al-Salameh, Abdallah [2 ,3 ]
Petit, Pascal [4 ,5 ]
Bonneterre, Vincent [4 ,6 ]
Cance, Christophe [5 ,6 ]
Decocq, Guillaume [7 ,8 ]
Boullier, Agnes [9 ,10 ]
Braun, Karine [10 ,11 ]
Desailloud, Rachel [2 ,3 ]
机构
[1] Amiens Univ Hosp, Reg Ctr Occupat & Environm Dis Hauts de france, 1 Rond Point Pr Christian Cabrol, F-80000 Amiens, France
[2] Univ Picardy Jules Verne, UPJV, INERIS, Peritox UMR I 01, 1 Rond Point Pr Christian Cabrol, F-80000 Amiens, France
[3] Amiens Univ Hosp, Dept Endocrinol Diabet Mellitus & Nutr, 1 Rond Point Pr Christian Cabrol, F-80054 Amiens, France
[4] CHU Grenoble Alpes, Ctr Reg Pathol Profess & Environm, F-38000 Grenoble, France
[5] Univ Grenoble Alpes, AGEIS, F-38000 Grenoble, France
[6] Univ Grenoble Alpes, CNRS, Grenoble INP, TIMC, F-38000 Grenoble, France
[7] Ctr Hosp Univ Amiens Picardie, Serv Pharmacol Clin, UF PRiMAX Prevent Risques lies Medicaments & Autre, 1 Rond Point Pr Christian Cabrol, F-80054 Picardie 1, France
[8] Jules Verne Univ Picardy, Ecol & Dynam Syst Anthropises EDYSAN, UMR CNRS 7058, 1 Rue Louvels, F-80037 Amiens 1, France
[9] Amiens Univ Hosp, Dept Biochem, 1 Rond Point Pr Christian Cabrol, F-80054 Amiens, France
[10] Amiens Univ Hosp, Reg Ctr Newborn Screening Picardy, 1 Rond Point Pr Christian Cabrol, F-80054 Amiens, France
[11] Amiens Univ Hosp, Dept Paediat, F-80054 Amiens, France
[12] Ctr Reg Pathol Profess & Environm Hauts de France, Serv Med legale, Site Amiens,1 Rond Point Pr Christian Cabrol, F-80000 Amiens, France
关键词
Prenatal exposure; Endocrine disruption; Pesticides; Perchlorates; Nitrates; Air pollution; IN-UTERO EXPOSURE; ORGANOCHLORINE PESTICIDES; DRINKING-WATER; CORD BLOOD; PUBERTAL DEVELOPMENT; NITRATE INTAKE; AIR-POLLUTION; WISTAR RATS; ASSOCIATION; ATRAZINE;
D O I
10.1016/j.scitotenv.2023.167089
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Objective: Systematic screening for congenital hypothyroidism by heel-stick sampling has revealed unexpected heterogeneity in the geographic distribution of newborn thyroid-stimulating hormone concentrations in Picardy, France. We explored a possible relationship with environmental pollutants.Methods: Zip code geolocation data from mothers of newborns without congenital hypothyroidism born in 2021 were linked to ecological data for a set of airborne (particulate matter with a diameter of 2.5 mu m or less [PM2.5] or 10 mu m or less [PM10]) and tap-water (nitrate and perchlorate ions and atrazine) pollutants. Statistical associations between mean exposure levels during the third trimester of pregnancy and Thyroid-stimulating hormone (TSH) concentrations in 6249 newborns (51 % male) were investigated using linear regression models.Results: Median neonatal TSH concentration (interquartile range, IQR) was 1.7 (1-2.8) mIU/L. An increase of one IQR in prenatal exposure to perchlorate ions (3.6 mu g/L), nitrate ions (19.2 mg/L), PM2.5 (3.7 mu g/m3) and PM10 (3.4 mu g/m3), were associated with increases in TSH concentrations of 2.30 % (95 % CI: 0.95-3.66), 5.84 % (95 % CI: 2.81-8.87), 13.44 % (95 % CI: 9.65-17.28) and 6.26 % (95 % CI: 3.01-9.56), respectively.Conclusions: Prenatal exposure to perchlorate and nitrate ions in tap water and to airborne PM over the third trimester of pregnancy was significantly associated with increased neonatal TSH concentrations.
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页数:9
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