Boron neutron capture therapy anti-tumor effect of nanostructured boron carbon nitride: A new potential candidate

被引：3

作者：

Kaur, Manjot ^{[1
]}

Meena, Ramovatar ^{[2
]}

Nishimura, Kai ^{[3
]}

Miura, Kazuki ^{[4
]}

Nakamura, Hiroyuki ^{[4
]}

Suzuki, Minoru ^{[5
]}

Sharma, Ram K. ^{[6
]}

Kumar, Akshay ^{[7
]}

机构：

[1] Chandigarh Univ, Univ Ctr Res & Dev, Mohali 140413, Punjab, India

[2] Jawaharlal Nehru Univ, Sch Environm Sci, Nanotoxicol Lab, New Delhi, India

[3] Tokyo Inst Technol, Sch Life Sci & Technol, Yokohama 2268503, Japan

[4] Tokyo Inst Technol, Inst Innovat Res, Lab Chem & Life Sci, Yokohama, Japan

[5] Kyoto Univ, Res Reactor Inst, Particle Radiat Oncol Res Ctr, Osaka, Japan

[6] Univ Petr & Energy Studies UPES, Ctr Interdisciplinary Res, Dehra Dun 248007, Uttarakhand, India

[7] Sardar Patel Univ, Dept Phys, Mandi 175001, Himachal Prades, India

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2023年 / 157卷

关键词：

BCN; Cytotoxicity; HeLa; U-87MG; BNCT; L-BPA; NANOSHEETS; NANOTUBES; CANCER; FILMS;

D O I：

10.1016/j.inoche.2023.111318

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Boron Neutron Capture Therapy (BNCT) is a targeted radiotherapy modality in which 10B enriched compounds are delivered for local treatment of the cancer cells. In this work, boron carbon nitride (BCN) has been explored as a potential boron compound for BNCT. BCN compound with high solubility has been synthesized by simple solvothermal method. Structural analysis show synthesis of hexagonal BCN with presence of defect states. Morphological analysis show formation of layered structure with highly porous network. The optical properties have also been studied and calculated band gap of material is similar to 3.85 eV. Cytotoxicity analysis show that synthesized material is relatively less toxic and can be explored for BNCT applications. The anti-tumor effect on HeLa and U-87MG cell lines show potential of BCN in comparison to clinically studied L-BPA compound.

引用

页数：6

共 35 条

[31]

Tauc J., 1974, AMORPHOUS LIQUID SEM, P159, DOI DOI 10.1007/978-1-4615-8705-7_4

[32] Synthesis and Characterization of Gd-Functionalized B4C Nanoparticles for BNCT Applications [J].

Vitali, Agostina ;

Demichelis, Maria Paola ;

Di Martino, Greta ;

Postuma, Ian ;

Bortolussi, Silva ;

Falqui, Andrea ;

Milanese, Chiara ;

Ferrara, Chiara ;

Sommi, Patrizia ;

Anselmi-Tamburini, Umberto .

LIFE-BASEL, 2023, 13 (02)

[33] The thermal and thermoelectric properties of in-plane C-BN hybrid structures and graphene/h-BN van der Waals heterostructures [J].

Wang, Jingang ;

Mu, Xijiao ;

Wang, Xinxin ;

Wang, Nan ;

Ma, Fengcai ;

Liang, Wenjie ;

Sun, Mengtao .

MATERIALS TODAY PHYSICS, 2018, 5 :29-57

[34]

Wang S., 2022, FRONT ONCOL, V12

[35] Boron neutron capture therapy for glioblastoma [J].

Yamamoto, Tetsuya ;

Nakai, Kei ;

Matsumura, Akira .

CANCER LETTERS, 2008, 262 (02) :143-152

← 1 2 3 4 →