The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3 x Tg-AD) mouse model strain

被引：4
|
作者：
Tian, Sheng [1 ,2 ,3 ]
Ye, Tianyuan [3 ]
Cheng, Xiaorui [1 ,2 ,3 ]
机构：
[1] Macau Univ Sci & Technol, Fac Chinese Med, Taipa 999078, Macao, Peoples R China
[2] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Jinan 250300, Peoples R China
来源：
EXPERIMENTAL NEUROLOGY | 2023年 / 368卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; 3 x Tg-AD mice; Cognition; Learning and memory; beta-Amyloid deposit; Tau hyperphosphorylation; MILD COGNITIVE IMPAIRMENT; 3XTG-AD MOUSE; TAU PHOSPHORYLATION; OBJECT RECOGNITION; MICE EXHIBIT; BETA; MEMORY; DEFICITS; AGE; ABNORMALITIES;
D O I：
10.1016/j.expneurol.2023.114505
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
As a classic animal model of Alzheimer's disease (AD), the 3 x Tg-AD mouse not only recapitulates most of anatomical hallmarks observed in AD pathology but also displays cognitive alterations in memory and learning tasks. The 3 x Tg-AD can better show the two characteristics of AD, amyloid beta (A beta) and neurofibrillary tangles (NFT). Therefore, 3 x Tg-AD strain is widely used in AD pathogenesis research and new drug development of AD. In this paper, the construction methods, pathological changes, and treatment characteristics of 3 x Tg-AD mouse models commonly used in AD research are summarized and commented, hoping to provide reference for researchers to choose and establish experimental patterns.
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页数：18
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