The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3 x Tg-AD) mouse model strain

被引：4
|
作者：
Tian, Sheng [1 ,2 ,3 ]
Ye, Tianyuan [3 ]
Cheng, Xiaorui [1 ,2 ,3 ]
机构：
[1] Macau Univ Sci & Technol, Fac Chinese Med, Taipa 999078, Macao, Peoples R China
[2] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Jinan 250300, Peoples R China
来源：
EXPERIMENTAL NEUROLOGY | 2023年 / 368卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; 3 x Tg-AD mice; Cognition; Learning and memory; beta-Amyloid deposit; Tau hyperphosphorylation; MILD COGNITIVE IMPAIRMENT; 3XTG-AD MOUSE; TAU PHOSPHORYLATION; OBJECT RECOGNITION; MICE EXHIBIT; BETA; MEMORY; DEFICITS; AGE; ABNORMALITIES;
D O I：
10.1016/j.expneurol.2023.114505
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
As a classic animal model of Alzheimer's disease (AD), the 3 x Tg-AD mouse not only recapitulates most of anatomical hallmarks observed in AD pathology but also displays cognitive alterations in memory and learning tasks. The 3 x Tg-AD can better show the two characteristics of AD, amyloid beta (A beta) and neurofibrillary tangles (NFT). Therefore, 3 x Tg-AD strain is widely used in AD pathogenesis research and new drug development of AD. In this paper, the construction methods, pathological changes, and treatment characteristics of 3 x Tg-AD mouse models commonly used in AD research are summarized and commented, hoping to provide reference for researchers to choose and establish experimental patterns.
引用
收藏
页数：18
相关论文
共 50 条
  • [1] The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model
    Cheng, Xiao-rui
    Zhou, Wen-xia
    Zhang, Yong-xiang
    AGEING RESEARCH REVIEWS, 2014, 13 : 13 - 37
  • [2] Exploring Dimethylsulfoniopropionate as a potential treatment for Alzheimer's disease: A study using the 3 x Tg-AD mouse model
    Sun, Fanfan
    Huang, Xuelian
    Wang, Hongshuang
    Lin, Baoyi
    Li, Hongyuan
    Wang, Xiaohui
    Liu, Qiong
    PHYTOMEDICINE, 2024, 130
  • [3] Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease
    Hugo Ferreira
    João Martins
    Ana Nunes
    Paula I. Moreira
    Miguel Castelo-Branco
    António Francisco Ambrósio
    Pedro Serranho
    Rui Bernardes
    Health and Technology, 2020, 10 : 875 - 883
  • [4] Retinal Aging in 3x Tg-AD Mice Model of Alzheimer's Disease
    Guimaraes, Pedro
    Serranho, Pedro
    Martins, Joao
    Moreira, Paula I.
    Ambrosio, Antonio Francisco
    Castelo-Branco, Miguel
    Bernardes, Rui
    FRONTIERS IN AGING NEUROSCIENCE, 2022, 14
  • [5] Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 x Tg-AD Mice
    Yu, Hongxia
    Shi, Jianhong
    Lin, Yiyou
    Zhang, Yehui
    Luo, Qihang
    Huang, Suo
    Wang, Sichen
    Wei, Jiale
    Huang, Junhao
    Li, Changyu
    Ji, Liting
    NEUROCHEMICAL RESEARCH, 2022, 47 (04) : 1049 - 1059
  • [6] Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer's Disease in 3 x Tg-AD Model Mice
    Goto, Tetsuya
    Kuramoto, Eriko
    Dhar, Ashis
    Wang, Rachel Pei-Hsuan
    Seki, Haruka
    Iwai, Haruki
    Yamanaka, Atsushi
    Matsumoto, Shin-Ei
    Hara, Hiromitsu
    Michikawa, Makoto
    Ohyagi, Yasumasa
    Leung, Wai Keung
    Chang, Raymond Chuen-Chung
    JOURNAL OF ALZHEIMERS DISEASE, 2020, 76 (04) : 1443 - 1459
  • [7] BEHAVIORAL AND PATHOLOGICAL CHANGES IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE
    Dong Xian-hui
    Gao Wei-juan
    Kong Wei-na
    Chai Xi-qing
    INDIAN JOURNAL OF ANIMAL RESEARCH, 2014, 48 (04) : 389 - 394
  • [8] A Derivative of the Brain Metabolite Lanthionine Ketimine Improves Cognition and Diminishes Pathology in the 3 x Tg-AD Mouse Model of Alzheimer Disease
    Hensley, Kenneth
    Gabbita, S. Prasad
    Venkova, Kalina
    Hristov, Alexandar
    Johnson, Ming F.
    Eslami, Pirooz
    Harris-White, Marni E.
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2013, 72 (10) : 955 - 969
  • [9] Icariin Ameliorates Alzheimer’s Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice
    Hongxia Yu
    Jianhong Shi
    Yiyou Lin
    Yehui Zhang
    Qihang Luo
    Suo Huang
    Sichen Wang
    Jiale Wei
    Junhao Huang
    Changyu Li
    Liting Ji
    Neurochemical Research, 2022, 47 : 1049 - 1059
  • [10] Alzheimer-like behavior and synaptic dysfunction in 3 x Tg-AD mice are reversed with calcineurin inhibition
    Zeng, Juan
    Hu, Xian-Feng
    Sun, Dong-Sheng
    Hong, Xiao-Yue
    Ma, Jun-Zheng
    Feng, Qiong
    EXPERIMENTAL BRAIN RESEARCH, 2024, 242 (06) : 1507 - 1515
12345