Enantioselective Total Synthesis of the Cephalotaxus Alkaloid (-)-Cephalotine A

被引：4

作者：

Sheng, Peng-Zhen ^{[1
,2
]}

Li, Lu-Lu ^{[1
]}

Ni, Zhi-Bin ^{[1
,2
]}

Wei, Kun ^{[1
]}

Yang, Yu-Rong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ORGANIC LETTERS | 2023年

基金：

中国国家自然科学基金;

关键词：

FORMAL TOTAL-SYNTHESIS; ALPHA-ALLYLATION; UNIFIED STRATEGY; NATURAL-PRODUCTS; GAMMA-LACTAMS; HECK REACTION; (+/-)-CEPHALOTAXINE; REARRANGEMENT; CONSTRUCTION; CYCLIZATION;

D O I：

10.1021/acs.orglett.3c02097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cephalotine A, a recently isolated Cephalotaxus alkaloid,was firstsynthesized enantioselectively through three critical reactions. SmI2 -mediated radical cyclization of lactone and aldehyde toforge the final ring system, Chang's iridium-catalyzed C-Hamidation to construct pyrrolidone stereoselectively, and Carreria'sdual Ir/amine catalyzed allylation to install the vicinal tertiarystereocenters.

引用

页码：7459 / 7463

页数：5

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