Synthesis and Bioactivities of Novel Pyrazole Oxime Derivatives Containing 1,3,4-Oxadiazole Group

In order to explore new pyrazole oxime compounds possessing satisfactory bioactivities, sixteen pyrazole oxime derivatives containing 1,3,4-oxadiazole group were prepared with fenpyroximate selected as lead structure. Their insecticidal activities were determined. Preliminary bioassay demonstrated that all the target compounds displayed 100% insecticidal activities towards Mythimna separata at 500 mu g/mL, of which 5 target compounds possessed 80%similar to 100% insecticidal activities against Mythimna separata at 100 mu g/mL. Moreover, at concentration of 500 mu g/mL, mortality rates against Aphis medicaginis of 9 target compounds were 100%, those of 3 compounds were 70%similar to 100% at 100 mu g/mL. Additionally, 4 target compounds exhibited more than 80% mortality rates against Tetranychus cinnabarinus at 500 mu g/mL.