Advanced Vaccine Design Strategies against SARS-CoV-2 and Emerging Variants

被引：4

作者：

Zhang, Jianzhong ^{[1
]}

Xia, Yutian ^{[1
]}

Liu, Xuan ^{[1
]}

Liu, Gang ^{[1
,2
]}

机构：

[1] Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China

[2] Xiamen Univ, Innovat Ctr Cell Biol, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Peoples R China

来源：

BIOENGINEERING-BASEL | 2023年 / 10卷 / 02期

基金：

中国国家自然科学基金;

关键词：

vaccine design; SARS-CoV-2; COVID-19; variants;

D O I：

10.3390/bioengineering10020148

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Vaccination is the most cost-effective means in the fight against infectious diseases. Various kinds of vaccines have been developed since the outbreak of COVID-19, some of which have been approved for clinical application. Though vaccines available achieved partial success in protecting vaccinated subjects from infection or hospitalization, numerous efforts are still needed to end the global pandemic, especially in the case of emerging new variants. Safe and efficient vaccines are the key elements to stop the pandemic from attacking the world now; novel and evolving vaccine technologies are urged in the course of fighting (re)-emerging infectious diseases. Advances in biotechnology offered the progress of vaccinology in the past few years, and lots of innovative approaches have been applied to the vaccine design during the ongoing pandemic. In this review, we summarize the state-of-the-art vaccine strategies involved in controlling the transmission of SARS-CoV-2 and its variants. In addition, challenges and future directions for rational vaccine design are discussed.

引用

页数：17

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