Renal aging and mitochondrial quality control

被引：2

作者：

Guo, Xiuli ^{[1
]}

Wang, Jiao ^{[2
]}

Wu, Yinjie ^{[3
]}

Zhu, Xinwang ^{[4
]}

Xu, Li ^{[5
]}

机构：

[1] China Med Univ, First Hosp, Dept Lab, Shenyang 110001, Peoples R China

[2] China Med Univ, Dept Obstet & Gynecol, Shengjing Hosp, Shenyang, Peoples R China

[3] China Med Univ, Dept Obstet, Hosp 1, Shenyang, Peoples R China

[4] China Med Univ, Dept Nephrol, Hosp 1, Shenyang, Peoples R China

[5] Guangdong Med Univ, Dept Lab Med, Affiliated Hosp 2, Zhanjiang 524003, Guangdong, Peoples R China

来源：

BIOGERONTOLOGY | 2024年 / 25卷 / 03期

基金：

中国博士后科学基金;

关键词：

Aging; Mitochondrial quality control; Mitochondrial dysfunction; Renal intrinsic cells; DIABETIC KIDNEY-DISEASE; FUNCTIONAL-CHANGES; OXIDATIVE STRESS; CELL SENESCENCE; EMERGING ROLE; MITOPHAGY; DYSFUNCTION; BIOGENESIS; DYNAMICS; METFORMIN;

D O I：

10.1007/s10522-023-10091-6

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Mitochondria are dynamic organelles that participate in different cellular process that control metabolism, cell division, and survival, and the kidney is one of the most metabolically active organs that contains abundant mitochondria. Perturbations in mitochondrial homeostasis in the kidney can accelerate kidney aging, and maintaining mitochondrial homeostasis can effectively delay aging in the kidney. Kidney aging is a degenerative process linked to detrimental processes. The significance of aberrant mitochondrial homeostasis in renal aging has received increasing attention. However, the contribution of mitochondrial quality control (MQC) to renal aging has not been reviewed in detail. Here, we generalize the current factors contributing to renal aging, review the alterations in MQC during renal injury and aging, and analyze the relationship between mitochondria and intrinsic renal cells. We also introduce MQC in the context of renal aging, and discuss the study of mitochondria in the intrinsic cells of the kidney, which is the innovation of our paper. In addition, during kidney injury and repair, the specific functions and regulatory mechanisms of MQC systems in resident and circulating cell types remain unclear. Currently, most of the studies we reviewed are based on animal and cellular models, the relationship between renal tissue aging and mitochondria has not been adequately investigated in clinical studies, and there is still a long way to go.

引用

页码：399 / 414

页数：16