Quantitative Magnetic Resonance Imaging for Neurodevelopmental Outcome Prediction in Neonates Born Extremely Premature-An Exploratory Study

被引：2

作者：

Schmidbauer, Victor U. ^{[1
]}

Yildirim, Mehmet S. ^{[1
]}

Dovjak, Gregor O. ^{[1
]}

Goeral, Katharina ^{[2
]}

Buchmayer, Julia ^{[2
]}

Weber, Michael ^{[1
]}

Kienast, Patric ^{[1
]}

Diogo, Mariana C. ^{[3
]}

Prayer, Florian ^{[1
]}

Stuempflen, Marlene ^{[1
]}

Kittinger, Jakob ^{[1
]}

Malik, Jakob ^{[1
]}

Nowak, Nikolaus M. ^{[1
]}

Klebermass-Schrehof, Katrin ^{[2
]}

Fuiko, Renate ^{[2
]}

Berger, Angelika ^{[2
]}

Prayer, Daniela ^{[1
]}

Kasprian, Gregor ^{[1
]}

Giordano, Vito ^{[2
]}

机构：

[1] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Waehringer Guertel 18-20, A-1090 Vienna, Austria

[2] Med Univ Vienna, Comprehens Ctr Pediat, Dept Pediat & Adolescent Med, Div Neonatol Intens Care & Neuropediat, Waehringer Guertel 18-20, A-1090 Vienna, Austria

[3] Hosp Garcia Orta, Dept Neuroradiol, Ave Torrado da Silva, P-2805267 Almada, Portugal

来源：

CLINICAL NEURORADIOLOGY | 2024年 / 34卷 / 02期

关键词：

Brain Stem; Extremely Premature; Magnetic Resonance Imaging; Newborn; Prognosis; WHITE-MATTER; BRAIN-STEM; PROTON-DENSITY; PRETERM; QUANTIFICATION; INFANTS; MATURATION; IMPACT; MRI; AGE;

D O I：

10.1007/s00062-023-01378-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose Neonates born at < 28 weeks of gestation are at risk for neurodevelopmental delay. The aim of this study was to identify quantitative MR-based metrics for the prediction of neurodevelopmental outcomes in extremely preterm neonates. Methods T1-/T2-relaxation times (T1R/T2R), ADC, and fractional anisotropy (FA) of the left/right posterior limb of the internal capsule (PLIC) and the brainstem were determined at term-equivalent ages in a sample of extremely preterm infants (n = 33). Scores for cognitive, language, and motor outcomes were collected at one year corrected-age. Pearson's correlation analyses detected relationships between quantitative measures and outcome data. Stepwise regression procedures identified imaging metrics to estimate neurodevelopmental outcomes. Results Cognitive outcomes correlated significantly with T2R (r = 0.412; p = 0.017) and ADC (r = -0.401; p = 0.021) (medulla oblongata). Furthermore, there were significant correlations between motor outcomes and T1R (pontine tegmentum (r = 0.346; p = 0.049), midbrain (r = 0.415; p = 0.016), right PLIC (r = 0.513; p = 0.002), and left PLIC (r = 0.504; p = 0.003)); T2R (right PLIC (r = 0.405; p = 0.019)); ADC (medulla oblongata (r = -0.408; p = 0.018) and pontine tegmentum (r = -0.414; p = 0.017)); and FA (pontine tegmentum (r = -0.352; p = 0.045)).T2R/ADC (medulla oblongata) (cognitive outcomes (R2 = 0.296; p = 0.037)) and T1R (right PLIC)/ADC (medulla oblongata) (motor outcomes (R2 = 0.405; p = 0.009)) revealed predictive potential for neurodevelopmental outcomes. Results Cognitive outcomes correlated significantly with (TR)-R-2 (r = 0.412; p = 0.017) and ADC (r = -0.401; p = 0.021) (medulla oblongata). Furthermore, there were significant correlations between motor outcomes and T1R (pontine tegmentum (r = 0.346; p = 0.049), midbrain (r = 0.415; p = 0.016), right PLIC (r = 0.513; p = 0.002), and left PLIC (r = 0.504; p = 0.003)); (TR)-R-2 (right PLIC (r = 0.405; p = 0.019)); ADC (medulla oblongata (r = -0.408; p = 0.018) and pontine tegmentum (r = -0.414; p = 0.017)); and FA (pontine tegmentum (r = -0.352; p = 0.045)).(TR)-R-2/ADC (medulla oblongata) (cognitive outcomes (R-2 = 0.296; p = 0.037)) and T1R (right PLIC)/ADC (medulla oblongata) (motor outcomes (R-2 = 0.405; p = 0.009)) revealed predictive potential for neurodevelopmental outcomes. Conclusion There are relationships between relaxometry-/DTI-based metrics determined by neuroimaging near term and neurodevelopmental outcomes collected at one year of age. Both modalities bear prognostic potential for the prediction of cognitive and motor outcomes. Thus, quantitative MRI at term-equivalent ages represents a promising approach with which to estimate neurologic development in extremely preterm infants.

引用

页码：421 / 429

页数：9

共 48 条

[41]

van der Knaap MS., 2005, MAGNETIC RESONANCE M, DOI [10.1007/3-540-27660-2, DOI 10.1007/3-540-27660-2]

[42] Adult outcome of preterm birth: Implications for neurodevelopmental theories of psychosis [J].