Liquid biopsy: from concept to clinical application

被引：36

作者：

Alix-Panabieres, Catherine ^{[1
,2
,3
,8
]}

Marchetti, Dario ^{[4
,5
]}

Lang, Julie E. ^{[6
,7
]}

机构：

[1] Univ Med Ctr Montpellier, Lab Rare Circulating Human Cells LCCRH, Montpellier, France

[2] Univ Montpellier, CNRS, CREEC CANECEV, MIVEGEC CREES,IRD, Montpellier, France

[3] European Liquid Biopsy Soc ELBS, Hamburg, Germany

[4] Univ New Mexico, Dept Internal Med, Hlth Sci Ctr, MSC07 4025,1 Univ New Mexico, Albuquerque, NM 87131 USA

[5] Univ New Mexico, Dept Pathol, Hlth Sci Ctr, UNM Comprehens Canc Ctr, MSC07 4025,1 Univ New Mexico, Albuquerque, NM 87131 USA

[6] Cleveland Clin, Breast Surg & Canc Biol, 9500 Euclid Ave,A80, Cleveland, OH USA

[7] Cleveland Clin, Case Comprehens Canc Ctr, 9500 Euclid Ave,A80, Cleveland, OH USA

[8] Inst Univ Rech Clin IURC, 641 Ave Doyen Gaston Giraud, F-34093 Montpellier 5, France

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

CIRCULATING TUMOR-CELLS; BREAST-CANCER; DNA;

D O I：

10.1038/s41598-023-48501-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The diagnosis and treatment of cancer presents a physical and mental burden to the patient, often involving diagnostic biopsies and surgeries or chemotherapeutic approaches with severe side-effects. Advances which enable early detection of cancer and close monitoring of the disease course without invasive procedures, and which can underpin a tailored approach to treatment, can therefore make a big difference to the quality of life of patients. Liquid biopsies can be used to access tumor cells and tumor DNA circulating in the blood. Monitoring these species can provide a minimally invasive and repeatable means to detect cancer, or gain information about its response to treatment.

引用

页数：4

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