Synthesis, Sensing Performance and DFT Studies of a Novel Coumarin-based Schiff Base As a Turn-on Fluorescence Probe for Zinc Ion Detection

被引:4
作者
Hashemi, Seyedeh Mahdieh [1 ]
Moradi, Seyed Ershad [1 ]
Ahangar, Roudabeh Mohsseni [2 ]
Farmanzadeh, Davood [2 ]
Emami, Saeed [1 ]
机构
[1] Mazandaran Univ Med Sci, Dept Med Chem & Pharmaceut Sci Res Ctr, Fac Pharm, Sari, Iran
[2] Univ Mazandaran, Dept Phys Chem, Fac Chem, Babolsar 4741695447, Iran
关键词
Coumarin; Chemosensor; Fluorescence; Zinc; Schiff base; DFT; SELECTIVE DETECTION; AQUEOUS-SOLUTION; METAL-IONS; CHEMOSENSOR; ZN2+; APPROXIMATION; RECOGNITION; SENSOR; MG2+;
D O I
10.1007/s10895-023-03510-x
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The design and development of novel efficient fluorescent chemical sensors for the selective detection of ions is currently of significant importance in supramolecular chemistry. Since zinc is a ubiquitous, indispensable and the second most abundant metal ion in the human body, developing chemosensors that can accurately discriminate between Zn2+ and Cd2+ ions has been a challenge due to their similar properties as they are in the same group of the periodic table. Therefore, a technique to trace and visualize free zinc ions is demanded. In this study, an innovative coumarin-based Schiff base (L) was synthesized and characterized by H-1 NMR, C-13 NMR and mass spectroscopy. A novel "Turn On" fluorescence chemosensor platform was developed for trace amounts of Zn2+ ions. The fluorescence Job's plot measurement was used to determine the complexation ratio between the probe and Zn2+ ion, which showed a maximum point indicating the formation of a ML2 adduct. Additionally, the geometrical parameters calculated using DFT and TD-DFT calculations were in close agreement with the experimentally observed values.
引用
收藏
页码:307 / 315
页数:9
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