Correlation between 18F-FDG PET-derived parameters and quantitative pathological characteristics of soft tissue sarcoma

被引：1

作者：

Chen, Bo ^{[1
]}

Tao, Juan ^{[2
]}

Wu, Tong ^{[3
]}

Feng, Hongbo ^{[1
]}

Xie, Jinghui ^{[1
]}

Zhong, Lin ^{[4
]}

Wang, Shaowu ^{[5
,6
]}

机构：

[1] Dalian Med Univ, Affiliated Hosp 1, Dept Nucl Med, Dalian, Peoples R China

[2] Dalian Med Univ, Affiliated Hosp 2, Dept Pathol, Dalian, Peoples R China

[3] Dalian Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Dalian, Peoples R China

[4] Dalian Med Univ, Affiliated Hosp 1, Dept Pathol, Dalian, Peoples R China

[5] Dalian Med Univ, Affiliated Hosp 2, Dept Radiol, Dalian, Peoples R China

[6] Dalian Med Univ, Affiliated Hosp 2, Dept Radiol, Zhongshan Rd 467, Dalian 116027, Peoples R China

来源：

QUANTITATIVE IMAGING IN MEDICINE AND SURGERY | 2023年 / 13卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Soft tissue sarcoma (STS); 18F-fluorodeoxyglucose (18F-FDG); positron emission tomography (PET); metabolic parameter; pathological characteristic;

D O I：

10.21037/qims-23-412

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Background: F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET) has been widely used for evaluating patients with soft tissue sarcoma (STS). However, uncertainties and overlap among individuals may be observed, and the relevance of these findings remains to be further explored. The present study was aimed at investigating the correlation between PET metabolic parameters and quantitative pathological characteristics in STS.Methods: We retrospectively collected 39 patients with STS who underwent 18F-FDG PET/computed tomography (CT) examination before treatment. Metabolic parameters including the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and intratumoral FDG uptake heterogeneity (IFH) were measured. Histological grading was performed according to the French Federation of Cancer Centers grading system. Continuous staining of tissue sections and digital quantitative analysis methods were used, the characteristics of tumor nucleated cells were observed through hematoxylin-eosin staining, and the expression of CD163, CD68, CD8, and CD4 in tumor tissues was determined by immunohistochemistry (IHC), then the correlation between FDG metabolic parameters and the above quantitative pathological characteristics in patients with STS were evaluated.Results: The SUVmax of F-18-FDG PET/CT in STS was positively correlated with the total nuclear area (r=0.355, P=0.027). SUVmax was also positively correlated with the expression levels of CD163, CD68, CD8, and CD4 (r=0.582, 0.485, 0.343, and 0.324, with P<0.001, 0.002, 0.032, and 0.044, respectively), but was not significantly correlated with cell count and mean nuclear area (all P>0.05). However, MTV, TLG, and IFH were not significantly correlated with the above quantitative pathological characteristics. Further multivariate logistic regression analysis indicated that only CD163 expression and histological grade were independently correlated with SUVmax. Moreover, SUVmax remained positively correlated with CD163 expression in the low-grade STS (r=0.820, P=0.001) and high-grade STS groups (r=0.430, P=0.028).Conclusions: F-18-FDG uptake was positively correlated with the quantitative pathological features of soft tissue tumors. SUVmax may be a meaningful method reflecting the level of M2 macrophage infiltration and may provide additional valuable information for preclinical evaluation of STS.

引用

页码：7842 / 7853

页数：12