Epigenetic regulation of breast cancer metastasis

被引：12
作者：
Thakur, Chitra [1 ]
Qiu, Yiran [1 ]
Pawar, Aashna [1 ]
Chen, Fei [1 ]
机构：
[1] SUNY Stony Brook, Stony Brook Canc Ctr, Renaissance Sch Med, Lauterbur Dr, Stony Brook, NY 11794 USA
来源：
CANCER AND METASTASIS REVIEWS | 2024年 / 43卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Breast cancer; Metastasis; Epigenetic regulation; EPITHELIAL-MESENCHYMAL TRANSITION; DISSEMINATED TUMOR-CELLS; SUBEROYLANILIDE HYDROXAMIC ACID; HISTONE DEACETYLASE INHIBITORS; HYPOXIA-INDUCIBLE FACTOR-1; INDUCED LYSYL OXIDASE; DNA METHYLATION; STEM-CELLS; BONE-MARROW; ABERRANT EXPRESSION;
D O I：
10.1007/s10555-023-10146-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among women worldwide. Recurrent metastasis is associated with poor patient outcomes and poses a significant challenge in breast cancer therapies. Cancer cells adapting to a new tissue microenvironment is the key event in distant metastasis development, where the disseminating tumor cells are likely to acquire genetic and epigenetic alterations during the process of metastatic colonization. Despite several decades of research in this field, the exact mechanisms governing metastasis are not fully understood. However, emerging body of evidence indicates that in addition to genetic changes, epigenetic reprogramming of cancer cells and the metastatic niche are paramount toward successful metastasis. Here, we review and discuss the latest knowledge about the salient attributes of metastasis and epigenetic regulation in breast cancer and crucial research domains that need further investigation.
引用
收藏
页码：597 / 619
页数：23
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