High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation

被引：60

作者：

Wang, Anli ^{[1
,2
]}

Wan, Xuzhi ^{[1
,2
]}

Zhuang, Pan ^{[1
,2
]}

Jia, Wei ^{[1
,2
]}

Ao, Yang ^{[3
,4
]}

Liu, Xiaohui ^{[3
,4
]}

Tian, Yimei ^{[1
,2
]}

Zhu, Li ^{[1
,2
]}

Huang, Yingyu ^{[1
,2
]}

Yao, Jianxin ^{[1
,2
]}

Wang, Binjie ^{[5
]}

Wu, Yuanzhao ^{[5
]}

Xu, Zhongshi ^{[5
]}

Wang, Jiye ^{[5
]}

Yao, Weixuan ^{[5
]}

Jiao, Jingjing ^{[3
,4
]}

Zhang, Yu ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Zhejiang Key Lab Agrofood Proc, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Dept Gastroenterol, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 2, Sch Publ Hlth, Dept Nutr,Sch Med, Hangzhou 310058, Zhejiang, Peoples R China

[4] Zhejiang Univ, Affiliated Hosp 2, Dept Endocrinol, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China

[5] Zhejiang Police Coll, Dept Criminal Sci & Technol, Key Lab Drug Prevent & Control Technol Zhejiang Pr, Hangzhou 310053, Zhejiang, Peoples R China

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2023年 / 120卷 / 18期

基金：

中国国家自然科学基金;

关键词：

fried foods; anxiety and depression; acrylamide; lipid metabolism disturbance; neuroinflammation; ARACHIDONIC-ACID METABOLISM; OXIDATIVE STRESS; ACRYLAMIDE; ZEBRAFISH; ASSOCIATION; EXPRESSION; NEUROTOXICITY; PEROXIDATION; INFLAMMATION; DISEASES;

D O I：

10.1073/pnas.2221097120

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Western dietary patterns have been unfavorably linked with mental health. However, the long-term effects of habitual fried food consumption on anxiety and depres-sion and underlying mechanisms remain unclear. Our population-based study with 140,728 people revealed that frequent fried food consumption, especially fried potato consumption, is strongly associated with 12% and 7% higher risk of anxiety and depression, respectively. The associations were more pronounced among male and younger consumers. Consistently, long-term exposure to acrylamide, a representative food processing contaminant in fried products, exacerbates scototaxis and thigmot-axis, and further impairs exploration ability and sociality of adult zebrafish, showing anxiety-and depressive-like behaviors. Moreover, treatment with acrylamide signif-icantly down-regulates the gene expression of tjp2a related to the permeability of blood-brain barrier. Multiomics analysis showed that chronic exposure to acrylamide induces cerebral lipid metabolism disturbance and neuroinflammation. PPAR signa-ling pathway mediates acrylamide-induced lipid metabolism disorder in the brain of zebrafish. Especially, chronic exposure to acrylamide dysregulates sphingolipid and phospholipid metabolism, which plays important roles in the development of anxi-ety and depression symptoms. In addition, acrylamide promotes lipid peroxidation and oxidation stress, which participate in cerebral neuroinflammation. Acrylamide dramatically increases the markers of lipid peroxidation, including (& PLUSMN;)5-HETE, 11(S)-HETE, 5-oxoETE, and up-regulates the expression of proinflammatory lipid mediators such as (& PLUSMN;)12-HETE and 14(S)-HDHA, indicating elevated cerebral inflammatory status after chronic exposure to acrylamide. Together, these results both epidemiologically and mechanistically provide strong evidence to unravel the mechanism of acrylamide-triggered anxiety and depression, and highlight the sig-nificance of reducing fried food consumption for mental health.

引用

页数：12

共 88 条

[11] Myelination in the absence of galactocerebroside and sulfatide: Normal structure with abnormal function and regional instability [J].