Renal Sarcoidosis-like Reaction Induced by PD-1 Inhibitor Treatment in Non-Small Cell Lung Cancer: A Case Report and Literature Review

被引：4

作者：

Park, Sang-Don ^{[1
]}

Kim, Mee-Seon ^{[2
]}

Han, Man-Hoon ^{[2
]}

Kim, Yong-Jin ^{[2
]}

Jung, Hee-Yeon ^{[1
]}

Choi, Ji-Young ^{[1
]}

Cho, Jang-Hee ^{[1
]}

Park, Sun-Hee ^{[1
]}

Kim, Chan-Duck ^{[1
]}

Kim, Yong-Lim ^{[1
]}

Lim, Jeong-Hoon ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Nephrol, Daegu 41944, South Korea

[2] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, Daegu 41944, South Korea

来源：

MEDICINA-LITHUANIA | 2023年 / 59卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

sarcoidosis-like reaction; immune checkpoint inhibitor; PD-1; inhibitor; kidney biopsy; lung cancer; IPILIMUMAB; BLOCKADE;

D O I：

10.3390/medicina59050991

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Monoclonal antibodies directed against immune checkpoint proteins have been widely used to treat various cancers and have resulted in favorable clinical outcomes. Despite these beneficial properties, immune checkpoint inhibitors (ICIs) can induce side effects called immune-related adverse events, including sarcoidosis-like reactions (SLR) across multiple organs. Here, we report a case of renal SLR after ICI treatment, and we review the related literature. A 66-year-old Korean patient with non-small cell lung cancer was referred to the nephrology clinic for renal failure after the 14th pembrolizumab treatment dose. A renal biopsy revealed multiple epithelioid cell granulomas, with several lymphoid aggregates in the renal interstitium and a moderate degree of inflammatory cell infiltration in the tubulointerstitium. A moderate dose of steroid therapy was initiated, and the serum creatinine level partially recovered after four weeks of treatment. Judicious monitoring of renal SLR is, therefore, required during ICI therapy, and a timely diagnosis by renal biopsy and appropriate treatment are important.

引用

页数：8

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