Role of Exosomes in the Invasion and Metastasis of Ovarian Cancer and Application Potential of Clinical Diagnosis and Treatment

被引：5

作者：

Zhu, Yifei ^{[1
,2
]}

Wang, Cheng ^{[1
,2
]}

Ma, Ziyu ^{[2
]}

Li, Feifei ^{[2
]}

Xu, Chunwei ^{[3
]}

Pan, Weiwei ^{[4
]}

Liu, Aijun ^{[2
]}

机构：

[1] Weifang Med Univ, Sch Basic Med Sci, Dept Pathol, Weifang 261053, Peoples R China

[2] Gen Hosp PLA, Med Ctr 7, Dept Pathol, Beijing 100700, Peoples R China

[3] Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Peoples R China

[4] Jiaxing Univ, Coll Med, Dept Cell Biol, Jiaxing 314001, Peoples R China

来源：

JOURNAL OF CANCER | 2023年 / 14卷 / 07期

基金：

中国博士后科学基金;

关键词：

Ovarian cancer; exosome; cancer therapy; metastasis; drug carrier; NICHE FORMATION; TUMOR MICROENVIRONMENT; ENGINEERING EXOSOMES; MESOTHELIAL CELLS; FIBROBLASTS; PROGRESSION; POLARIZATION; MACROPHAGES; BIOMARKERS; FIBRONECTIN;

D O I：

10.7150/jca.83663

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ovarian cancer is a highly lethal form of cancer in females, largely due to extensive metastases that often accompany the initial diagnosis. Exosomes are microvesicles size from 30 to 100nm, which can be secreted by most cells. These special extracellular vesicles play a vital role in the metastasis of ovarian cancer. In this study, we conducted a comprehensive review of current research pertaining to the role of exosomes in ovarian cancer, utilizing the PubMed (R) and Web of Science databases. Our review highlights the progress in elucidating the mechanisms by which exosomes facilitate ovarian cancer progression. Additionally, we discuss the potential of exosomes as a novel therapeutic target for ovarian cancer treatment. Overall, our review provides valuable insights into the current state of research on exosomes in ovarian cancer therapy.

引用

页码：1141 / 1150

页数：10

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