Alkaloids and Styryl lactones from Goniothalamus ridleyi King and Their α-Glucosidase Inhibitory Activity

被引：1

作者：

Polbuppha, Isaraporn ^{[1
,2
]}

Teerapongpisan, Passakorn ^{[1
,2
]}

Phukhatmuen, Piyaporn ^{[1
,2
]}

Suthiphasilp, Virayu ^{[3
]}

Maneerat, Tharakorn ^{[1
,2
,4
]}

Charoensup, Rawiwan ^{[4
,5
]}

Andersen, Raymond J. J. ^{[6
,7
]}

Laphookhieo, Surat ^{[1
,2
,4
]}

机构：

[1] Mae Fah Luang Univ, Ctr Chem Innovat Sustainabil CIS, Chiang Rai 57100, Thailand

[2] Mae Fah Luang Univ, Sch Sci, Chiang Rai 57100, Thailand

[3] Pathumwan Inst Technol, Fac Sci & Technol, Dept Ind Technol & Innovat Management, Bangkok 10330, Thailand

[4] Mae Fah Luang Univ, Med Plant Innovat Ctr, Chiang Rai 57100, Thailand

[5] Mae Fah Luang Univ, Sch Integrat Med, Chiang Rai 57100, Thailand

[6] Univ British Columbia, Dept Chem, 2036, Main Mall, Vancouver, BC V6T 1Z1, Canada

[7] Univ British Columbia, Dept Earth Ocean & Atmospher Sci, 2036, Main Mall, Vancouver, BC V6T 1Z1, Canada

来源：

MOLECULES | 2023年 / 28卷 / 03期

关键词：

Goniothalamus ridleyi; dimeric aristolactam; styryl lactone; alpha-glucosidase inhibitory activity; BIOACTIVE STYRYLLACTONES; ROOTS;

D O I：

10.3390/molecules28031158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gonioridleylactam (1), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of Goniothalamus ridleyi King. The structure of gonioridleylactam (1) consists of two different aristolactams linked together with two methylenedioxy bridges at C-3/C-3' and C-4/C-4', generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1H-benz[f]indole-4,9-dione, 2), together with eight known compounds (3-10) were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds 1-4, 7, and 9 were evaluated for their alpha-glucosidase inhibitory activity.Of these, 3,5demethoxypiperolide (7) displayed the highest alpha-glucosidase inhibitory activity, with an IC50 value of 1.25 mu M.

引用

页数：8

共 26 条

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