Pan-cancer analyses reveal IGSF10 as an immunological and prognostic biomarker

被引：3
作者：
Zhou, Yongxia [1 ,2 ,3 ,4 ,5 ]
Gao, Manzhi [2 ,3 ,4 ,5 ]
Jing, Yaoyao [2 ,3 ,4 ,5 ,6 ]
Wang, Xiaofang [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Tianjin Med Univ, Dept Hematol, Canc Inst & Hosp, Tianjin, Peoples R China
[2] Tianjin Med Univ, Natl Clin Res Ctr Canc, Canc Inst & Hosp, Tianjin, Peoples R China
[3] Tianjins Clin Res Ctr Canc, Tianjin, Peoples R China
[4] Tianjin Med Univ, Key Lab Breast Canc Prevent & Therapy, Minist Educ, Tianjin, Peoples R China
[5] Key Lab Canc Immunol & Biotherapy, Tianjin, Peoples R China
[6] Tianjin Med Univ, Canc Inst & Hosp, Day Ward, Tianjin, Peoples R China
来源：
FRONTIERS IN GENETICS | 2023年 / 13卷
关键词：
IGSF10; pan-cancer; prognosis; immune infiltration; TMB; MSI; drug sensitivity; TUMOR-INFILTRATING LYMPHOCYTES; MISMATCH REPAIR; MUTATIONAL BURDEN; IMMUNOTHERAPY; EXPRESSION;
D O I：
10.3389/fgene.2022.1032382
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Background: IGSF10 is a member of the immunoglobulin superfamily. Over the previous decade, growing proof has validated definitive correlations between individuals of the immunoglobulin superfamily and human diseases. However, the function of IGSF10 in pan-cancer stays unclear. We aimed to analyze the immunological and prognostic value of IGSF10 in pan-cancer.Methods: We utilized a vary of bioinformatic ways to inspect the function of IGSF10 in pan-cancer, including its correlation with prognosis, immune cell infiltration, tumor mutational burden (TMB), microsatellite instability (MSI), mismatch repair (MMR), DNA methyltransferases, genetic alteration, drug sensitivity, etc.Results: We noticed low expression of IGSF10 in most cancer types. IGSF10 expression in tumor samples correlates with prognosis in most cancers. In most cancer types, IGSF10 expression was strongly related to immune cells infiltration, immune checkpoints, immune modulators, TMB, MSI, MMR, and DNA methyltransferases, among others. Functional enrichment analyses indicated that IGSF10 expression was involved in lymphocyte differentiation, cell molecules adhesion, etc. Furthermore, low IGSF10 expression could increase the drug sensitivity of many drugs.Conclusion: IGSF10 could serve as a novel prognostic marker and attainable immunotherapy target for several malignancies.
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页数：21
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