A case report of anti-N-methyl-D-aspartate receptor encephalitis with chromosomally integrated human herpesvirus 6

被引：0

作者：

Iwao, Kazunori ^{[1
]}

Watanabe, Mitsuru ^{[1
]}

Mukaino, Takahiko ^{[1
]}

Fujii, Takayuki ^{[1
]}

Yamasaki, Ryo ^{[1
]}

Isobe, Noriko ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Neurol Inst, Dept Neurol, Fukuoka, Japan

来源：

NEUROLOGY AND CLINICAL NEUROSCIENCE | 2023年 / 11卷 / 01期

关键词：

anti-N-methyl-D-aspartate receptor encephalitis; autoimmune encephalitis; case report; cerebrospinal fluid; chromosomally integrated human herpesvirus 6; DIAGNOSIS;

D O I：

10.1111/ncn3.12681

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chromosomally integrated human herpesvirus 6 (ciHHV6) is a condition where HHV6-DNA is integrated into the host germline genome. ciHHV6 can be misdiagnosed as active HHV6 infection. We report a 30-year-old woman presenting with psychological symptoms without a history of immunodeficiency. She had an ovarian teratoma and anti-N-methyl-D-aspartate receptor (NMDAR) antibodies in the cerebrospinal fluid (CSF) with HHV6-DNA in the serum and CSF. The final diagnosis was anti-NMDAR encephalitis and ciHHV6 because laparoscopic oophorectomy and immunotherapy ameliorated her symptoms and HHV6-DNA was detected in her oral mucosa cells. This case suggests the need to assess whether HHV6-DNA is related to infection or ciHHV6 when HHV6-DNA is detected in the CSF of patients with encephalitis.

引用

页码：52 / 54

页数：3