Sustainable Production of Microcrystalline Cellulose Through Gas Phase Hydrolysis for Pharmaceutical Applications: Characterization and Life Cycle Assessment (Mar, 10.1007/s10924-024-03228-2, 2024)

被引：0

作者：

Hosseinzadeh, Jaber ^{[1
]}

Abdulkhani, Ali ^{[1
]}

Ashori, Alireza ^{[2
]}

Dmirievich, Pimenov Sergey ^{[3
]}

Hajiahmad, Ali ^{[4
]}

Abdolmaleki, Hamid ^{[5
]}

Sun, Fubao ^{[6
]}

Zadeh, Zahra Echresh ^{[7
]}

机构：

[1] Univ Tehran, Dept Wood & Paper Sci & Technol, Fac Nat Resources, Karaj, Iran

[2] Dept Chem Technol Iranian Res Org Sci & Technol IR, Dept Chem Technol, Tehran, Iran

[3] St Petersburg State Forest Tech Univ, Inst Chem Proc Wood Biomass & Technosphere Safety, St Petersburg, Russia

[4] Univ Tehran, Fac Agr, Dept Mech Biosyst Engn, Karaj, Iran

[5] MAPNA Rail Technol Co, Karaj, Iran

[6] Jiangnan Univ, Sch Biotechnol, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Peoples R China

[7] UCL, Dept Chem Engn, Torrington Pl, London WC1E 7JE, England

来源：

JOURNAL OF POLYMERS AND THE ENVIRONMENT | 2024年 / 32卷 / 06期

关键词：

Cotton linters; Gas phase hydrolysis; Hydrochloric acid; Life cycle assessment; Microcrystalline cellulose;

D O I：

10.1007/s10924-024-03303-8

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Conventional microcrystalline cellulose (MCC) production via aqueous mineral acid hydrolysis is energy- and water-intensive, generating high wastewater volumes. An alternative green chemistry approach employs concentrated gaseous acids to enhance yield and conserve resources. This work aimed to develop an efficient, sustainable gas-phase hydrochloric acid (HCl)-air hydrolysis process for MCC production from cotton linters. MCC yield, structure, powder properties, tablet performance, and environmental impacts were characterized. The gas phase method successfully produced 96% MCC yield and 87% crystallinity, higher than commercial MCC (93% yield, 39% crystallinity). MCC powder exhibited 141 mu m mean diameter, 0.91 m2/g surface area, and 245 degrees C onset decomposition. Tablet testing revealed balanced ductility and toughness. Reduced water (40 kg/kg cellulose), energy (188 MJ/kg MCC), and wastewater generation (39 kg/kg cellulose) were achieved versus conventional production. Tablet testing of MCC compacts revealed balanced ductility and toughness during compression. The HCl-air approach enabled high-yield, high-purity MCC synthesis under mild conditions while enhancing powder attributes, tablet performance, and sustainability compared to commercial manufacturing.

引用

页码：2746 / 2747

页数：2