The potential role of Listeria monocytogenes in promoting colorectal adenocarcinoma tumorigenic process

被引:1
作者
Baldelli, Giulia [1 ]
De Santi, Mauro [1 ]
Ateba, Collins Njie [2 ]
Cifola, Giorgia [1 ]
Amagliani, Giulia [1 ]
Tchatchouang, Christ-Donald Kaptchouang [2 ]
Montso, Peter Kotsoana [2 ]
Brandi, Giorgio [1 ]
Schiavano, Giuditta Fiorella [3 ]
机构
[1] Univ Urbino Carlo Bo, Dept Biomol Sci, Urbino, PU, Italy
[2] North West Univ, Fac Nat & Agr Sci, Food Secur & Safety Focus Area, Mmabatho, South Africa
[3] Univ Urbino Carlo Bo, Dept Humanities, Urbino, PU, Italy
关键词
Listeria monocytogenes; Colorectal cancer; Tumorigenic process; CANCER; PROLIFERATION; EXPRESSION; BACTERIA; SPLEEN;
D O I
10.1186/s12866-024-03240-5
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Background Listeria monocytogenes is a foodborne pathogen, which can cause a severe illness, especially in people with a weakened immune system or comorbidities. The interactions between host and pathogens and between pathogens and tumor cells have been debated in recent years. However, it is still unclear how bacteria can interact with tumor cells, and if this interaction can affect tumor progression and therapy. Methods In this study, we evaluated the involvement of L. monocytogenes in pre-neoplastic and colorectal cancer cell proliferation and tumorigenic potential. Results Our findings showed that the interaction between heat-killed L. monocytogenes and pre-neoplastic or colorectal cancer cells led to a proliferative induction; furthermore, by using a three-dimensional cell culture model, the obtained data indicated that L. monocytogenes was able to increase the tumorigenic potential of both pre-neoplastic and colorectal cancer cells. The observed effects were then confirmed as L. monocytogenes-specific, using Listeria innocua as negative control. Lastly, data suggested the Insulin Growth Factor 1 Receptor (IGF1R) cascade as one of the possible mechanisms involved in the effects induced by L. monocytogenes in the human colorectal adenocarcinoma cell line. Conclusions These findings, although preliminary, suggest that the presence of pathogenic bacterial cells in the tumor niches may directly induce, increase, and stimulate tumor progression.
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页数:12
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