SARS-CoV-2 Infection and Preeclampsia-How an Infection Can Help Us to Know More about an Obstetric Condition

被引：5

作者：

Gonzalez-Vanegas, Otilia ^{[1
]}

Martinez-Perez, Oscar ^{[2
]}

机构：

[1] Hosp San Cecilio, Obstet Dept, Granada 1, Granada 18016, Spain

[2] Hosp Univ Puerta Hierro 2, Obstet Dept, Majadahonda 28222, Spain

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 07期

关键词：

SARS-CoV-2; COVID-19; preeclampsia; pregnancy; inflammation; myocardial injury; PREGNANCY COMPLICATIONS; COVID-19; DISEASE; INTERLEUKIN-6; OUTCOMES; WOMEN;

D O I：

10.3390/v15071564

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pregnant women with SARS-CoV-2 infection have a significantly higher risk of maternal death, ICU admission, preterm delivery, and stillbirth compared to those without infection. Additionally, the risk of preeclampsia (PE) increases in pregnant women infected with SARS-CoV-2, particularly in severe cases. The association between COVID-19 and PE is likely attributed to various mechanisms, including direct effects of the virus on trophoblast function and the arterial wall, exaggerated inflammatory response in pregnant women, local inflammation leading to placental ischemia, SARS-CoV-2-related myocardial injury, cytokine storm, and thrombotic microangiopathy. This paper aims to explore the similarities between PE and SARS-CoV-2 infection, considering COVID-19 as a valuable study model. By examining these parallels, we can enhance our knowledge and comprehension of PE. We wish to emphasize the potential for COVID-19-induced myocardial injury in pregnant women and its connection to the increased maternal mortality rate.

引用

页数：17

共 76 条

[1] COVID-19 Cases and Disease Severity in Pregnancy and Neonatal Positivity Associated With Delta (B.1.617.2) and Omicron (B.1.1.529) Variant Predominance [J].

Adhikari, Emily H. ;

MacDonald, Lorre ;

SoRelle, Jeffrey A. ;

Morse, Jessica ;

Pruszynski, Jessica ;

Spong, Catherine Y. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 327 (15) :1500-1502

[2] Myocardial infarction redefined -: A consensus Document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction [J].

Alpert, JS ;

Antman, E ;

Apple, F ;

Armstrong, PW ;

Bassand, JP ;

de Luna, AB ;

Beller, G ;

Breithardt, G ;

Chaitman, BR ;

Clemmensen, P ;

Falk, E ;

Fishbein, MC ;

Galvani, M ;

Garson, A ;

Grines, C ;

Hamm, C ;

Jaffe, A ;

Katus, H ;

Kjekshus, J ;

Klein, W ;

Klootwijk, P ;

Lenfant, C ;

Levy, D ;

Levy, RI ;

Luepker, R ;

Marcus, F ;

Näslund, U ;

Ohman, M ;

Pahlm, O ;

Poole-Wilson, P ;

Popp, R ;

Alto, P ;

Pyörälä, K ;

Ravkilde, J ;

Rehnquist, N ;

Roberts, W ;

Roberts, R ;

Roelandt, J ;

Rydén, L ;

Sans, S ;

Simoons, ML ;

Thygesen, K ;

Tunstall-Pedoe, H ;

Underwood, R ;

Uretsky, BF ;

Van de Werf, F ;

Voipio-Pulkki, LM ;

Wagner, G ;

Wallentin, L ;

Wijns, W .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (03) :959-969

[3] Critical Care in SARS-CoV-2 Infected Pregnant Women: A Prospective Multicenter Study [J].

Alvarez Bartolome, Ana ;

Abdallah Kassab, Nadia Akram ;

Cruz Melguizo, Sara ;

de la Cruz Conty, Maria Luisa ;

Forcen Acebal, Laura ;

Abascal Saiz, Alejandra ;

Pintado Recarte, Pilar ;

Martinez Varea, Alicia ;

Cerrillos Gonzalez, Lucas ;

Garcia Fernandez, Javier ;

Martinez Perez, Oscar .

BIOMEDICINES, 2022, 10 (02)

[4] Re: Pre-eclampsia-like syndrome induced by severe coronavirus disease 2019: a prospective observational study [J].

Amorim, Melania Maria ;

Takemoto, Maira Libertad Soligo ;

Katz, Leila .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2020, 127 (12) :1577-1577

[5]

[Anonymous], 2021, WHO Coronavirus (COVID-19) Dashboard

[6] Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection [J].

Badr, Dominique A. ;

Picone, Olivier ;

Bevilacqua, Elisa ;

Carlin, Andrew ;

Meli, Federica ;

Sibiude, Jeanne ;

Mattern, Jeremie ;

Fils, Jean-Francois ;

Mandelbrot, Laurent ;

Lanzone, Antonio ;

De Luca, Daniele ;

Jani, Jacques C. ;

Vivanti, Alexandre J. .

EMERGING INFECTIOUS DISEASES, 2021, 27 (10) :2535-2543

[7] The role of interleukins in preeclampsia: A comprehensive review [J].

Bellos, Ioannis ;

Karageorgiou, Vasilios ;

Kapnias, Dimitrios ;

Karamanli, Konstantina-Eleni ;

Siristatidis, Charalampos .

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2018, 80 (06)

[8] Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia [J].

Bloise, Enrrico ;

Zhang, Jianhong ;

Nakpu, Jittanan ;

Hamada, Hirotaka ;

Dunk, Caroline E. ;

Li, Siliang ;

Imperio, Guinever E. ;

Nadeem, Lubna ;

Kibschull, Mark ;

Lye, Phetcharawan ;

Matthews, Stephen G. ;

Lye, Stephen J. .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2021, 224 (03) :298.e1-298.e8

[9] Maternal left ventricular hypertrophy and diastolic dysfunction and brain natriuretic peptide concentration in early- and late-onset pre-eclampsia [J].

Borges, V. T. M. ;

Zanati, S. G. ;

Peracoli, M. T. S. ;

Poiati, J. R. ;

Romao-Veiga, M. ;

Peracoli, J. C. ;

Thilaganathan, B. .

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2018, 51 (04) :519-523

[10] Echocardiographic Structure and Function in Hypertensive Disorders of Pregnancy: A Systematic Review [J].

Castleman, James S. ;

Ganapathy, Ramesh ;

Taki, Fatima ;

Lip, Gregory Y. H. ;

Steeds, Richard P. ;

Kotecha, Dipak .

CIRCULATION-CARDIOVASCULAR IMAGING, 2016, 9 (09)

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