Extracranial metastasis of pediatric glioblastoma: case report and literature review

被引:2
作者
Huang, Wei-Zhi [1 ]
Chen, Hung-Chieh [2 ,3 ]
Chang, Te-Kau [4 ]
You, Weir Chiang [5 ]
Jan, Yee-Jee [6 ]
Chou, Yu-Cheng [7 ,8 ,9 ,10 ]
机构
[1] Taichung Vet Gen Hosp, Dept Med Educ, Taichung, Taiwan
[2] Taichung Vet Gen Hosp, Dept Radiol, Taichung, Taiwan
[3] Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei, Taiwan
[4] China Med Univ, Pediat Pulmonol, Childrens Hosp Taichung, Taichung, Taiwan
[5] Taichung Vet Gen Hosp, Dept Radiat Oncol, Taichung, Taiwan
[6] Taichung Vet Gen Hosp, Dept Pathol & Lab Med, Taichung, Taiwan
[7] Taichung Vet Gen Hosp, Neurol Inst, Dept Neurosurg, 1650,Sec 4,Taiwan Blvd, Taichung 407, Taiwan
[8] Natl Chi Nan Univ, Dept Appl Chem, Nantou, Taiwan
[9] Natl Chung Hsing Univ, Coll Med, Dept Postbaccalaureate Med, Taichung, Taiwan
[10] Triserv Gen Hosp, Natl Def Med Ctr, Dept Neurol Surg, Taipei, Taiwan
关键词
Glioblastoma; Pediatric; Extracranial metastases; Lymph nodes; Spine; Lung; Multimodal treatment; MULTIFORME; GLIOMA;
D O I
10.1007/s00381-023-06229-z
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Glioblastoma (GBM) is a rare primary brain tumor in children, and extracranial metastases of pediatric GBM are particularly uncommon. We present the case of a 10-year-old girl with pediatric GBM who developed multiple extracranial metastases, including cervical lymph nodes, spine, and lung. We discuss the rarity of extracranial metastases in GBM and explore possible mechanisms of dissemination. The patient underwent surgical resections, radiotherapy, and chemotherapy, but the metastatic disease progressed despite treatment. We emphasize the need to consider extracranial metastases in pediatric GBM patients and adopt multimodal treatment approaches for managing this rare clinical entity. As the survival rates of pediatric GBM patients are improving, awareness of extracranial metastases is crucial for optimizing treatment outcomes.
引用
收藏
页码:933 / 937
页数:5
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