The KRAS signaling pathway's impact on the characteristics of pancreatic cancer cells

被引：2

作者：

Chen, ZhangXing ^{[1
]}

Chen, Meiyan ^{[1
]}

Fu, Yuka ^{[1
]}

Zhang, Jingyi ^{[1
]}

机构：

[1] Xiamen Univ, Dept Gastroenterol, Success Hosp, Xiamen 361000, Fujian, Peoples R China

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 248卷

关键词：

Pancreatic cancer; Signaling; KRAS; Therapy; ONCOGENIC KRAS; RAS MUTATIONS; TUMOR-GROWTH; K-RAS; INHIBITION; ACTIVATION; LUNG; GEMCITABINE; RESISTANCE; MECHANISM;

D O I：

10.1016/j.prp.2023.154603

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is classified as a cancer with high metastasis so that its mortality rate is high and most of the patients could not survive longer than 5 years. RAS signaling participate in cellular processes, so it has a key role in PDAC.RAS activation is associated via three different signaling pathway including somatic oncogenic point mutations in KRAS, upstream signaling like EGFR, oncogenic activation of the downstream B-RAF molecule. Several targeted therapies have been developed against kinase effectors particularly those in the MAPK and PI3K (phosphoinositide 3-kinase)/mTOR signaling pathways and several inhibitors are undergoing clinical studies at the moment. However, because it is highly metastatic and frequently diagnosed at advanced disease stages, pancreatic cancer continues to be a challenging cancer to treat. This article will explore therapeutic approaches that focus on oncogenic KRAS signaling in pancreatic cancer and provide an updated synopsis of our knowledge of how mutant KRAS function in the illness.

引用

页数：6

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