In Vivo 18F-Florzolotau Tau Positron Emission Tomography Imaging in Parkinson's Disease Dementia

被引：10

作者：

Tang, Yilin ^{[1
,2
,3
]}

Li, Ling ^{[4
]}

Hu, Tianyu ^{[1
,2
,3
]}

Jiao, Fangyang ^{[5
]}

Han, Linlin ^{[1
,2
,3
]}

Li, Shiyu ^{[1
,2
,3
]}

Xu, Zhiheng ^{[1
,2
,3
]}

Fan, Yun ^{[1
,2
,3
]}

Sun, Yimin ^{[1
,2
,3
]}

Liu, Fengtao ^{[1
,2
,3
]}

Yen, Tzu-Chen ^{[6
]}

Zuo, Chuantao ^{[5
]}

Wang, Jian ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Dept Neurol, Shanghai, Peoples R China

[2] Fudan Univ, Natl Res Ctr Aging & Med, Shanghai, Peoples R China

[3] Fudan Univ, Natl Ctr Neurol Disorders, State Key Lab Med Neurobiol, Huashan Hosp, Shanghai, Peoples R China

[4] Wuhan Univ, Zhongnan Hosp, Dept Nucl Med, Wuhan, Peoples R China

[5] Fudan Univ, Huashan Hosp, PET Ctr, Shanghai, Peoples R China

[6] APRINOIA Therapeut Co Ltd, Suzhou, Peoples R China

来源：

MOVEMENT DISORDERS | 2023年 / 38卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Parkinson's disease dementia; F-18-florzolotau; tau PET imaging; PATHOLOGY; LEWY; NEUROPATHOLOGY;

D O I：

10.1002/mds.29273

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Tau pathology is observed during autopsy in many patients with Parkinson's disease dementia (PDD). Positron emission tomography (PET) imaging using the tracer F-18-florzolotau has the potential to capture tau accumulation in the living brain. Objective: The aim was to describe the results of F-18-florzolotau PET/CT (computed tomography) imaging in patients with PDD. Methods: Ten patients with PDD, 9 with Parkinson's disease with normal cognition (PD-NC), and 9 age-matched healthy controls (HCs) were enrolled. Clinical assessments and F-18-florzolotau PET/CT imaging were performed. Results: F-18-Florzolotau uptake was significantly higher in the cortical regions of patients with PDD compared with both PD-NC and HCs, especially in the temporal lobe. Notably, F-18-florzolotau uptake in the occipital lobe of patients with PDD showed a significant correlation with cognitive impairment as reflected by Mini-Mental State Examination (MMSE) scores. Conclusions: F-18-Florzolotau PET imaging can effectively capture the occurrence of tau pathology in patients with PDD, which was also linked to MMSE scores. (c) 2022 International Parkinson and Movement Disorder Society.

引用

页码：147 / 152

页数：7

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