Elevated Kynurenine Levels in Patients with Primary Sjogren's Syndrome

被引：6
作者：
Apaydin, Hakan [1 ]
Bicer, Cemile Koca [2 ]
Yurt, Emine Feyza [2 ]
Serdar, Muhittin Abdulkadir [3 ]
Dogan, Ismail [4 ]
Erten, Sukran [4 ]
机构：
[1] Ankara City Hosp, Dept Rheumatol, Ankara, Turkey
[2] Ankara Yildirim Beyazit Univ, Dept Biochem, Ankara City Hosp, Ankara, Turkey
[3] Acibadem Univ, Dept Biochem, Istanbul, Turkey
[4] Ankara Yildirim Beyazit Univ, Ankara City Hosp, Dept Rheumatol, Ankara, Turkey
来源：
LABORATORY MEDICINE | 2023年 / 54卷 / 02期
关键词：
autoimmune; IDO; kynurenine; Sjogren's syndrome; tryptophan; T-CELL; INDOLEAMINE 2,3-DIOXYGENASE; TRYPTOPHAN DEGRADATION; RHEUMATOID-ARTHRITIS; METABOLISM; MECHANISMS; DIAGNOSIS; RESPONSES; CONSENSUS; BRAIN;
D O I：
10.1093/labmed/lmac084
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objective We aimed to investigate the plasma levels of tryptophan (Trp) and its metabolites in patients with primary Sjogren's syndrome (pSS). Methods The study included 34 pSS patients and 42 healthy individuals, and serum Trp and kynurenine (Kyn) concentrations were measured by liquid chromatography with tandem mass spectrometry. Trp degradation was predicted using the ratio of Kyn and Trp concentrations (Kyn/Trp). Results In our study, the mean serum Trp concentration was found to be considerably lower in the pSS group than in the control group (P = .001). The levels of Kyn (P = .019) and the Kyn/Trp ratio (P < .001) were significantly higher in the pSS group than in the control group. The Kyn/Trp ratio was negatively correlated with C-reactive protein (r = -0.369, P = .032). Conclusion We found that Kyn pathway metabolism was altered in patients with pSS. This suggests that Trp metabolism may be closely linked to the disease pathogenesis of pSS.
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收藏
页码：166 / 172
页数：7
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