The prognostic role of the immunohistochemical expression of S100 in meningiomas

被引:5
作者
Behling, Felix [1 ,2 ,3 ]
Fodi, Christina [1 ,2 ]
Skardelly, Marco [1 ,2 ]
Paulsen, Frank [1 ,4 ]
Tabatabai, Ghazaleh [1 ,2 ,3 ,5 ,6 ,7 ]
Honegger, Juergen [1 ,2 ]
Tatagiba, Marcos [1 ,2 ]
Schittenhelm, Jens [1 ,6 ,8 ]
机构
[1] Eberhard Karls Univ Tubingen, Univ Hosp Tubingen, Ctr Neurooncol, Comprehens Canc Ctr Tubingen Stuttgart, Tubingen, Germany
[2] Eberhard Karls Univ Tubingen, Univ Hosp Tubingen, Dept Neurosurg, Hoppe Seyler St 3, Tubingen, Germany
[3] Hertie Inst Clin Brain Res, Tubingen, Germany
[4] Eberhard Karls Univ Tubingen, Univ Hosp Tubingen, Dept Radiat Oncol, Tubingen, Germany
[5] Eberhard Karls Univ Tubingen, Univ Hosp Tubingen, Dept Neurol & Interdisciplinary Neurooncol, Tubingen, Germany
[6] German Canc Consortium DKTK, DKFZ Partner Site Tubingen, Tubingen, Germany
[7] Eberhard Karls Univ Tubingen, Cluster Excellence EXC Image Guided & Funct Instr, Tubingen, Germany
[8] Eberhard Karls Univ Tubingen, Univ Hosp Tubingen, Dept Neuropathol, Tubingen, Germany
关键词
Meningioma; S100; Prognosis; Recurrence-free survival; Tissue microarray; DIAGNOSIS;
D O I
10.1007/s00432-022-04186-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Despite best clinical management, meningioma patients experience tumor recurrence. Efforts have been made to improve the prognostic stratification of meningiomas. Recently, a multi-faceted molecular classification suggested that the marker S100 is associated with a favorable outcome, making a further analysis in a larger cohort interesting. Materials and methods The immunohistochemical staining for S100 was analyzed in 1669 paraffin-embedded meningioma samples. The distribution and association with clinical data and progression-free survival via radiographic tumor recurrence were assessed. Results Of 1669 cases, 218 tumors showed strong S100 expression (13.1%). A significantly higher frequency of S100 positive meningiomas was observed in meningiomas of female patients, tumors with spinal and convexity/falx location, primary tumor surgery, NF2, higher extent of resection, lower WHO CNS grade, adjuvant radiotherapy and recurrence-free tumors during follow-up. Univariate analysis revealed a favorable progression-free survival for meningiomas with S100 expression (p = 0.0059) but not in the multivariate analysis. Higher S100 frequency was independently associated with female gender (p = 0.0003), NF2 (p < 0.0001), tumor location (p < 0.0001) and lower WHO CNS grade (p = 0.0133). Conclusions The positive prognostic impact of S100 is mostly attributed to the confounding clinical factors gender, tumor location, NF2 status and WHO CNS grade.
引用
收藏
页码:2975 / 2985
页数:11
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