Philadelphia chromosome-positive T-cell acute lymphoblastic leukemia: a case report

被引：0

作者：

Dong, Qianze ^{[1
]}

Darwish, Tarneem ^{[1
,2
]}

Howard, Meyerson ^{[1
,2
]}

Shetty, Shashirekha ^{[1
,2
]}

Wang, Yang ^{[1
]}

Xiu, Yan ^{[1
]}

Gallogly, Molly ^{[3
]}

Zhao, Chen ^{[1
,2
,4
,5
]}

机构：

[1] Case Western Reserve Univ, Dept Pathol, Cleveland, OH USA

[2] Univ Hosp Cleveland Med Ctr, Dept Pathol, Cleveland, OH USA

[3] Univ Hosp Cleveland Med Ctr, Dept Hematol & Oncol, Cleveland, OH USA

[4] Louis Stokes Vet Affairs Med Ctr, Dept Pathol, Cleveland, OH USA

[5] Wolstein Res Bldg,Room 6523,2103 Cornell Rd, Cleveland, OH 44106 USA

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2024年 / 52卷 / 02期

关键词：

T-cell acute lymphoblastic leukemia; BCR-ABL1; Philadelphia chromosome; chronic myeloid leukemia; case report; diagnosis; BLAST PHASE; CHILDREN; IMATINIB; ADULTS;

D O I：

10.1177/03000605231156757

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Philadelphia chromosome-positive (Ph+) T-cell acute lymphoblastic leukemia (T-ALL) is a rare and aggressive type of acute leukemia. The Philadelphia chromosome is the hallmark of chronic myeloid leukemia (CML). The differentiation between Ph+ T-ALL and T-cell lymphoblastic crisis of CML may be problematic in some cases. Here, we report a rare case of de novo Ph+ T-ALL that presented a diagnostic challenge. The overall clinical, immunophenotypic, cytogenetic, and xenotransplantation results suggest a diagnosis of Ph+ T-ALL. The patient was treated with induction chemotherapy including imatinib followed by haploidentical stem cell transplantation and achieved complete remission.

引用

页数：5

共 16 条

[1]

Alshomar Ahmad, 2022, Hematol Oncol Stem Cell Ther, V15, P59, DOI 10.1016/j.hemonc.2020.02.004

[2] Outcome of treatment in children with philadelphia chromosome-positive acute lymphoblastic leukemia [J].

Aricò, M ;

Valsecchi, MG ;

Camitta, B ;

Schrappe, M ;

Chessells, J ;

Baruchel, A ;

Gaynon, P ;

Silverman, L ;

Janka-Schaub, G ;

Kamps, W ;

Pui, CH ;

Masera, G .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (14) :998-1006

[3] Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study [J].

Biondi, Andrea ;

Schrappe, Martin ;

De Lorenzo, Paola ;

Castor, Anders ;

Lucchini, Giovanna ;

Gandemer, Virginie ;

Pieters, Rob ;

Stary, Jan ;

Escherich, Gabriele ;

Campbell, Myriam ;

Li, Chi-Kong ;

Vora, Ajay ;

Arico, Maurizio ;

Roettgers, Silja ;

Saha, Vaskar ;

Valsecchi, Maria Grazia .

LANCET ONCOLOGY, 2012, 13 (09) :936-945

[4]

clinicaltrials, Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

[5] Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007 [J].

Dores, Graca M. ;

Devesa, Susan S. ;

Curtis, Rochelle E. ;

Linet, Martha S. ;

Morton, Lindsay M. .

BLOOD, 2012, 119 (01) :34-43

[6] Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study [J].

Fielding, Adele K. ;

Richards, Susan M. ;

Chopra, Rajesh ;

Lazarus, Hillard M. ;

Litzow, Mark R. ;

Buck, Georgina ;

Durrant, I. Jill ;

Luger, Selina M. ;

Marks, David I. ;

Franklin, Ian M. ;

McMillan, Andrew K. ;

Tallman, Martin S. ;

Rowe, Jacob M. ;

Goldstone, Anthony H. .

BLOOD, 2007, 109 (03) :944-950

[7]

Gagnier JJ, 2013, DTSCH ARZTEBL INT, V110, P603, DOI [10.3238/arztebl.2013.0603, 10.1111/head.12246, 10.1136/bcr-2013-201554, 10.7453/gahmj.2013.008, 10.1186/1752-1947-7-223]

[8] T-lymphoid or T/myeloid blast phase of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy: a report of 14 cases [J].

Gong, Z. ;

Xie, W. ;

Wang, W. ;

Chen, Z. ;

Xu, J. ;

Yuan, J. ;

Zhou, Y. ;

Wang, D. ;

Medeiros, L. J. ;

Hu, S. .

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2017, 39 (02) :e45-e50

[9] Clinical characteristics of Philadelphia positive T-cell lymphoid leukemias-(De novo and blast phase CML) [J].

Jain, Preetesh ;

Kantarjian, Hagop ;

Jabbour, Elias ;

Kanagal-Shamanna, Rashmi ;

Patel, Keyur ;

Pierce, Sherry ;

Garcia-Manero, Guillermo ;

Borthakur, Gautam ;

Ravandi, Farhad ;

O'Brien, Susan ;

Cortes, Jorge .

AMERICAN JOURNAL OF HEMATOLOGY, 2017, 92 (01) :E3-E4

[10] The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms [J].

Khoury, Joseph D. ;

Solary, Eric ;

Abla, Oussama ;

Akkari, Yassmine ;

Alaggio, Rita ;

Apperley, Jane F. ;

Bejar, Rafael ;

Berti, Emilio ;

Busque, Lambert ;

Chan, John K. C. ;

Chen, Weina ;

Chen, Xueyan ;

Chng, Wee-Joo ;

Choi, John K. ;

Colmenero, Isabel ;

Coupland, Sarah E. ;

Cross, Nicholas C. P. ;

De Jong, Daphne ;

Elghetany, M. Tarek ;

Takahashi, Emiko ;

Emile, Jean-Francois ;

Ferry, Judith ;

Fogelstrand, Linda ;

Fontenay, Michaela ;

Germing, Ulrich ;

Gujral, Sumeet ;

Haferlach, Torsten ;

Harrison, Claire ;

Hodge, Jennelle C. ;

Hu, Shimin ;

Jansen, Joop H. ;

Kanagal-Shamanna, Rashmi ;

Kantarjian, Hagop M. ;

Kratz, Christian P. ;

Li, Xiao-Qiu ;

Lim, Megan S. ;

Loeb, Keith ;

Loghavi, Sanam ;

Marcogliese, Andrea ;

Meshinchi, Soheil ;

Michaels, Phillip ;

Naresh, Kikkeri N. ;

Natkunam, Yasodha ;

Nejati, Reza ;

Ott, German ;

Padron, Eric ;

Patel, Keyur P. ;

Patkar, Nikhil ;

Picarsic, Jennifer ;

Platzbecker, Uwe .

LEUKEMIA, 2022, 36 (07) :1703-1719

← 1 2 →