Successful Treatment With Venetoclax Plus Azacytidine Combined With Radiation Therapy and Donor Lymphocyte Infusion in a Patient With Extramedullary Relapse of Acute Myeloid Leukemia After Stem Cell Transplantation

被引：0

作者：

Shirato, Shotaro ^{[1
]}

Iyama, Satoshi ^{[1
,2
]}

Fujimi, Akihito ^{[3
]}

Takahashi, Satoshi ^{[2
,4
]}

Kobune, Masayoshi ^{[1
]}

机构：

[1] Sapporo Med Univ, Dept Hematol, Sch Med, Sapporo, Japan

[2] Sapporo Med Univ Hosp, Div Lab Med, Sapporo, Japan

[3] Sapporo Kiyota Hosp, Dept Hematol, Sapporo, Japan

[4] Sapporo Med Univ, Sch Med, Dept Infect Control & Lab Med, Sapporo, Japan

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2024年 / 16卷 / 02期

关键词：

donor lymphocyte infusion; radiation therapy; venetoclax; stem cell transplantation; acute myeloid leukemia; extramedullary relapse; BCL-2; INHIBITION; RADIOTHERAPY; TARGETS;

D O I：

10.7759/cureus.53655

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Extramedullary (EM) relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute myeloid leukemia (AML) is rare and causes systemic relapse. Consequently, the prognosis is very poor because limited treatment is feasible in post -transplant patients. The efficacy and safety of venetoclax (VEN), a newly developed oral inhibitor of B -cell leukemia/lymphoma-2, plus azacytidine (AZA) in patients newly diagnosed with AML who are ineligible for intensive chemotherapy have been reported. We report a case in which VEN + AZA salvage treatment following radiation therapy and donor lymphocyte infusion afforded promising results in a patient with AML who showed post-allo-HSCT EM relapse.

引用

页数：4

共 17 条

[1] How I treat extramedullary acute myeloid leukemia [J].

Bakst, Richard L. ;

Tallman, Martin S. ;

Douer, Dan ;

Yahalom, Joachim .

BLOOD, 2011, 118 (14) :3785-3793

[2] BCL-2 family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignancies [J].

Bogenberger, J. M. ;

Kornblau, S. M. ;

Pierceall, W. E. ;

Lena, R. ;

Chow, D. ;

Shi, C-X ;

Mantei, J. ;

Ahmann, G. ;

Gonzales, I. M. ;

Choudhary, A. ;

Valdez, R. ;

Camoriano, J. ;

Fauble, V. ;

Tiedemann, R. E. ;

Qiu, Y. H. ;

Coombes, K. R. ;

Cardone, M. ;

Braggio, E. ;

Yin, H. ;

Azorsa, D. O. ;

Mesa, R. A. ;

Stewart, A. K. ;

Tibes, R. .

LEUKEMIA, 2014, 28 (08) :1657-1665

[3] Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia [J].

DiNardo, C. D. ;

Jonas, B. A. ;

Pullarkat, V. ;

Thirman, M. J. ;

Garcia, J. S. ;

Wei, A. H. ;

Konopleva, M. ;

Doehner, H. ;

Letai, A. ;

Fenaux, P. ;

Koller, E. ;

Havelange, V. ;

Leber, B. ;

Esteve, J. ;

Wang, J. ;

Pejsa, V. ;

Hajek, R. ;

Porkka, K. ;

Illes, A. ;

Lavie, D. ;

Lemoli, R. M. ;

Yamamoto, K. ;

Yoon, S. -S. ;

Jang, J. -H. ;

Yeh, S. -P. ;

Turgut, M. ;

Hong, W. -J. ;

Zhou, Y. ;

Potluri, J. ;

Pratz, K. W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (07) :617-629

[4] Salvage use of venetoclax-based therapy for relapsed AML post allogeneic hematopoietic cell transplantation [J].

Joshi, Maansi ;

Cook, Joselle ;

McCullough, Kristen ;

Nanaa, Ahmad ;

Gangat, Naseema ;

Foran, James M. ;

Murthy, Hemant S. ;

Kharfan-Dabaja, Mohamed A. ;

Sproat, Lisa ;

Palmer, Jeanne ;

Pardanani, Animesh ;

Tefferi, Ayalew ;

Begna, Kebede ;

Elliot, Michelle ;

Al-Kali, Aref ;

Patnaik, Mrinal ;

Shah, Mithun V. ;

Hogan, William J. ;

Litzow, Mark R. ;

Alkhateeb, Hassan B. .

BLOOD CANCER JOURNAL, 2021, 11 (03)

[5] Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse [J].

Kaufmann, SH ;

Karp, JE ;

Svingen, PA ;

Krajewski, S ;

Burke, PJ ;

Gore, SD ;

Reed, JC .

BLOOD, 1998, 91 (03) :991-1000

[6] Graft-versus-leukemia effects of transplantation and donor lymphocytes [J].

Kolb, Hans-Jochem .

BLOOD, 2008, 112 (12) :4371-4383

[7] Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia [J].

Kuusanmaki, Heikki ;

Leppa, Aino-Maija ;

Polonen, Petri ;

Kontro, Mika ;

Dufva, Olli ;

Deb, Debashish ;

Yadav, Bhagwan ;

Bruck, Oscar ;

Kumar, Ashwini ;

Everaus, Hele ;

Gjertsen, Bjorn T. ;

Heinaniemi, Merja ;

Porkka, Kimmo ;

Mustjoki, Satu ;

Heckman, Caroline A. .

HAEMATOLOGICA, 2020, 105 (03) :708-720

[8] BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells [J].

Lagadinou, Eleni D. ;

Sach, Alexander ;

Callahan, Kevin ;

Rossi, Randall M. ;

Neering, Sarah J. ;

Minhajuddin, Mohammad ;

Ashton, John M. ;

Pei, Shanshan ;

Grose, Valerie ;

O'Dwyer, Kristen M. ;

Liesveld, Jane L. ;

Brookes, Paul S. ;

Becker, Michael W. ;

Jordan, Craig T. .

CELL STEM CELL, 2013, 12 (03) :329-341

[9] Abscopal effect of radiotherapy combined with immune checkpoint inhibitors [J].

Liu, Yang ;

Dong, Yinping ;

Kong, Li ;

Shi, Fang ;

Zhu, Hui ;

Yu, Jinming .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2018, 11

[10] Long-term remission of extramedullary cutaneous relapse of acute myeloid leukaemia (leukaemia cutis) treated with decitabine-venetoclax [J].

Maravalle, Denise ;

Filosa, Alessandra ;

Bigazzi, Catia ;

Collina, Guido ;

Galieni, Piero .

EJHAEM, 2022, 3 (02) :517-520

← 1 2 →