Regulation of insulin secretion by the post-translational modifications

被引：11
作者：
Yang, Chunhua [1 ]
Wei, Mengna [1 ]
Zhao, Yanpu [1 ]
Yang, Zhanyi [1 ]
Song, Mengyao [1 ]
Mi, Jia [1 ]
Yang, Xiaoyong [2 ]
Tian, Geng [1 ]
机构：
[1] Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai, Shandong, Peoples R China
[2] Yale Univ, Yale Ctr Mol & Syst Metab, Dept Comparat Med, Dept Cellular & Mol Physiol,Sch Med, New Haven, CT 06520 USA
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷
基金：
中国国家自然科学基金;
关键词：
PTMs; phosphorylation; acetylation; ubiquitination; sumoylation; O-GlcNAcylation; palmitoylation; insulin secretion; PANCREATIC BETA-CELLS; ELEMENT-BINDING PROTEIN; UBIQUITIN-PROTEASOME PATHWAY; LINKED N-ACETYLGLUCOSAMINE; CAMP-RESPONSIVE ELEMENT; O-GLCNACYLATION; TRANSCRIPTIONAL REGULATION; EMERGING MECHANISMS; GENE-TRANSCRIPTION; COACTIVATOR CRTC1;
D O I：
10.3389/fcell.2023.1217189
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Post-translational modification (PTM) has a significant impact on cellular signaling and function regulation. In pancreatic beta cells, PTMs are involved in insulin secretion, cell development, and viability. The dysregulation of PTM in beta cells is clinically associated with the development of diabetes mellitus. Here, we summarized current findings on major PTMs occurring in beta cells and their roles in insulin secretion. Our work provides comprehensive insight into understanding the mechanisms of insulin secretion and potential therapeutic targets for diabetes from the perspective of protein PTMs.
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页数：12
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共 160 条
[1]   FoxOs at the crossroads of cellular metabolism, differentiation, and transformation [J].
Accili, D ;
Arden, KC .
CELL, 2004, 117 (04) :421-426
[2]   Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes [J].
Al-Khalili, Lubna ;
Barbosa, Thais de Castro ;
Ostling, Jorgen ;
Massart, Julie ;
Garrido Cuesta, Pablo ;
Osler, Megan E. ;
Katayama, Mutsumi ;
Nystrom, Ann-Christin ;
Oscarsson, Jan ;
Zierath, Juleen R. .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2014, 307 (09) :C774-C787
[3]   The Creb1 coactivator Crtc1 is required for energy balance and fertility [J].
Altarejos, Judith Y. ;
Goebel, Naomi ;
Conkright, Michael D. ;
Inotiel, Hiroshi ;
Xie, Jianxin ;
Arias, Carlos M. ;
Sawchenko, Paul E. ;
Montminy, Marc .
NATURE MEDICINE, 2008, 14 (10) :1112-1117
[4]   CREB and the CRTC co-activators: sensors for hormonal and metabolic signals [J].
Altarejos, Judith Y. ;
Montminy, Marc .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (03) :141-151
[5]   SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion [J].
Anderson, Kristin A. ;
Huynh, Frank K. ;
Fisher-Wellman, Kelsey ;
Stuart, J. Darren ;
Peterson, Brett S. ;
Douros, Jonathan D. ;
Wagner, Gregory R. ;
Thompson, J. Will ;
Madsen, Andreas S. ;
Green, Michelle F. ;
Sivley, R. Michael ;
Ilkayeva, Olga R. ;
Stevens, Robert D. ;
Backos, Donald S. ;
Capra, John A. ;
Olsen, Christian A. ;
Campbell, Jonathan E. ;
Muoio, Deborah M. ;
Grimsrud, Paul A. ;
Hirschey, Matthew D. .
CELL METABOLISM, 2017, 25 (04) :838-+
[6]   Glucose regulation of insulin gene expression in pancreatic β-cells [J].
Andrali, Sreenath S. ;
Sampley, Megan L. ;
Vanderford, Nathan L. ;
Ozcan, Sabire .
BIOCHEMICAL JOURNAL, 2008, 415 (1-10) :1-10
[7]   Glucose mediates the translocation of NeuroD1 by O-linked glycosylation [J].
Andrali, Sreenath S. ;
Qian, Qingwen ;
Ozcan, Sabire .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (21) :15589-15596
[8]   MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes [J].
Ardestani, Amin ;
Paroni, Federico ;
Azizi, Zahra ;
Kaur, Supreet ;
Khobragade, Vrushali ;
Yuan, Ting ;
Frogne, Thomas ;
Tao, Wufan ;
Oberholzer, Jose ;
Pattou, Francois ;
Conte, Julie Kerr ;
Maedler, Kathrin .
NATURE MEDICINE, 2014, 20 (04) :385-+
[9]   SUMOylation of Pancreatic Glucokinase Regulates Its Cellular Stability and Activity [J].
Aukrust, Ingvild ;
Bjorkhaug, Lise ;
Negahdar, Maria ;
Molnes, Janne ;
Johansson, Bente B. ;
Muller, Yvonne ;
Haas, Wilhelm ;
Gygi, Steven P. ;
Sovik, Oddmund ;
Flatmark, Torgeir ;
Kulkarni, Rohit N. ;
Njolstad, Pal R. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (08) :5951-5962
[10]   Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis [J].
Balaji, Vishnu ;
Pokrzywa, Wojciech ;
Hoppe, Thorsten .
BIOESSAYS, 2018, 40 (05)
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