Effects of maternal hypertension on cord blood Arginine vasopressin receptor expression

被引:2
作者
Gumusoglu, Serena [1 ]
Davis, Lauren [1 ]
Schickling, Brandon [1 ]
Devor, Eric [1 ]
Von Tersch, Lydia
Santillan, Mark [1 ]
Santillan, Donna [1 ,2 ]
机构
[1] Univ Iowa, Dept Obstet & Gynecol, Iowa City, IA USA
[2] 200 Hawkins Dr, Iowa City, IA 52242 USA
关键词
Preeclampsia; Gestational hypertension; Pregnancy; Vasopressin; Cord blood; PREECLAMPSIA; RISK; BIOMARKER; DISEASE; STROKE;
D O I
10.1016/j.preghy.2022.11.005
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Arginine vasopressin (AVP) signaling is altered in preeclampsia and physiologic stress. AVP is implicated in fluid homeostasis and cardiovascular (CV) function, which is disrupted in some progeny from preeclamptic preg-nancies. However, whether altered fetal AVP signaling occurs in preeclampsia is unknown. Here, we measured CV-related transcripts (e.g., AVP receptors) in cord blood via quantitative PCR. Chronic hypertension decreased AVPR1b, AVPR2, OXTR, LNPEP, and CUL5. AVPR1a, AVPR1b, and AVPR2 were decreased while OXTR was increased in preeclamptic cord blood. In sum, we found prenatal exposure to hypertension in pregnancy alters fetal AVP signaling and may thereby prime offspring CV disease risk.
引用
收藏
页码:1 / 3
页数:3
相关论文
共 15 条
  • [1] Anderson CM, 2007, JOGNN-J OBST GYN NEO, V36, P3, DOI [10.1111/j.1552-6909.2006.00115.x, 10.1111/J.1552-6909.2006.00115.x]
  • [2] Risk of cardiovascular disease, end-stage renal disease, and stroke in postpartum women and their fetuses after a hypertensive pregnancy
    Cunningham, Mark W., Jr.
    LaMarca, Babbette
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2018, 315 (03) : R521 - R528
  • [3] Hypoxia in utero increases the risk of pulmonary hypertension in rat offspring and is associated with vasopressin type-2 receptor upregulation
    Ding, Hao
    Luo, Yuchuan
    Hu, Ke
    Huang, Huaying
    Liu, Pei
    Xiong, Mengqing
    Zhu, Li
    Yi, Jing
    Xu, Ying
    [J]. MOLECULAR MEDICINE REPORTS, 2020, 22 (05) : 4173 - 4182
  • [4] Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming
    Escudero, Carlos
    Roberts, James M.
    Myatt, Leslie
    Feoktistov, Igor
    [J]. FRONTIERS IN PHARMACOLOGY, 2014, 5
  • [5] Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure
    Gumusoglu, Serena B.
    Chilukuri, Akanksha S. S.
    Santillan, Donna A.
    Santillan, Mark K.
    Stevens, Hanna E.
    [J]. TRENDS IN NEUROSCIENCES, 2020, 43 (04) : 253 - 268
  • [6] Pre-Eclampsia Is Associated With Increased Risk of Stroke in the Adult Offspring The Helsinki Birth Cohort Study
    Kajantie, Eero
    Eriksson, Johan G.
    Osmond, Clive
    Thornburg, Kent
    Barker, David J. P.
    [J]. STROKE, 2009, 40 (04) : 1176 - 1180
  • [7] Li X., CIRCULATION
  • [8] Biomarker discovery for disease status and symptom severity in children with autism
    Oztan, Ozge
    Jackson, Lisa P.
    Libove, Robin A.
    Sumiyoshi, Raena D.
    Phillips, Jennifer M.
    Garner, Joseph P.
    Hardan, Antonio Y.
    Parker, Karen J.
    [J]. PSYCHONEUROENDOCRINOLOGY, 2018, 89 : 39 - 45
  • [9] Cardiovascular Sequels During and After Preeclampsia
    Paauw, Nina D.
    Lely, A. Titia
    [J]. SEX-SPECIFIC ANALYSIS OF CARDIOVASCULAR FUNCTION, 2018, 1065 : 455 - 470
  • [10] Effects of endocrine-disrupting chemicals on hypothalamic oxytocin and vasopressin systems
    Reilly, Michael P.
    Kunkel, M. Nicole
    Thompson, Lindsay M.
    Zentay, Andrew
    Weeks, Connor D.
    Crews, David
    Cormack, Lawrence K.
    Gore, Andrea C.
    [J]. JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY, 2022, 337 (01) : 75 - 87